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acs arcus [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38264, updated on 9-Dec-2024

Summary

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Official Symbol
acsprovided by FlyBase
Official Full Name
arcusprovided by FlyBase
Primary source
FLYBASE:FBgn0035300
Locus tag
Dmel_CG1139
See related
AllianceGenome:FB:FBgn0035300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1139; Dmel\CG1139
Summary
Enables amino acid transmembrane transporter activity. Involved in amino acid transmembrane transport and regulation of growth. Located in basal labyrinth; organelle membrane; and plasma membrane. Is expressed in adult abdomen; adult head; and adult thorax. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to several human genes including SLC36A1 (solute carrier family 36 member 1); SLC36A2 (solute carrier family 36 member 2); and SLC36A3 (solute carrier family 36 member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See acs in Genome Data Viewer
Location:
62B12-62B12; 3-1.0 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1971638..1974285)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1971638..1974285)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Succinyl-CoA:3-ketoacid CoA transferase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44535

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes. Ögmundsdóttir MH, et al. PLoS One, 2012. PMID 22574197, Free PMC Article
  2. Systemic muscle wasting and coordinated tumour response drive tumourigenesis. Newton H, et al. Nat Commun, 2020 Sep 16. PMID 32938923, Free PMC Article
  3. Fast drosophila enterocyte regrowth after infection involves a reverse metabolic flux driven by an amino acid transporter. Socha C, et al. iScience, 2023 Sep 15. PMID 37636057, Free PMC Article
  4. PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids. Goberdhan DC, et al. Development, 2005 May. PMID 15843412
  5. Mitochondrial-Nuclear Interactions Mediate Sex-Specific Transcriptional Profiles in Drosophila. Mossman JA, et al. Genetics, 2016 Oct. PMID 27558138, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables amino acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables amino acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in basal labyrinth IDA
Inferred from Direct Assay
more info
 PubMed 
located_in organelle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
arcus
Names
CG1139-PA
acs-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1971638..1974285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139429.2 → NP_647686.1  arcus [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647686.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W056
    Related
    FBpp0072724
    Conserved Domains (2) summary
    COG0814
    Location:36 → 404
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    cl00456
    Location:42 → 444
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W056.1 Q9W056

Gene LinkOut

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