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Zfp488 zinc finger protein 488 [ Mus musculus (house mouse) ]

Gene ID: 382867, updated on 9-Dec-2024

Summary

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Official Symbol
Zfp488provided by MGI
Official Full Name
zinc finger protein 488provided by MGI
Primary source
MGI:MGI:2686052
See related
Ensembl:ENSMUSG00000044519 AllianceGenome:MGI:2686052
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1206; Znf488
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Involved in positive regulation of myelination and positive regulation of oligodendrocyte differentiation. Acts upstream of or within negative regulation of DNA-templated transcription and oligodendrocyte development. Located in nucleus. Is expressed in central nervous system and optic nerve. Orthologous to human ZNF488 (zinc finger protein 488). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Zfp488 in Genome Data Viewer
Location:
14 B; 14 20.8 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (33689023..33700986, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (33967070..33979034, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene growth differentiation factor 2 Neighboring gene retinol binding protein 3, interstitial Neighboring gene predicted gene, 30083 Neighboring gene STARR-seq mESC enhancer starr_36360 Neighboring gene predicted gene 5460 Neighboring gene RIKEN cDNA A630023A22 gene Neighboring gene anthrax toxin receptor-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination. Soundarapandian MM, et al. Sci Rep, 2011. PMID 22355521, Free PMC Article
  2. The myelination-associated G protein-coupled receptor 37 is regulated by Zfp488, Nkx2.2, and Sox10 during oligodendrocyte differentiation. Schmidt AL, et al. Glia, 2024 Jul. PMID 38546197
  3. An oligodendrocyte-specific zinc-finger transcription regulator cooperates with Olig2 to promote oligodendrocyte differentiation. Wang SZ, et al. Development, 2006 Sep. PMID 16908628
  4. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The myelination-associated G protein-coupled receptor 37 is regulated by Zfp488, Nkx2.2, and Sox10 during oligodendrocyte differentiation.
    Title: The myelination-associated G protein-coupled receptor 37 is regulated by Zfp488, Nkx2.2, and Sox10 during oligodendrocyte differentiation.
  2. Zfp488 functions as an oligodendrocyte-specific transcription co-regulator important for oligodendrocyte maturation
    Title: An oligodendrocyte-specific zinc-finger transcription regulator cooperates with Olig2 to promote oligodendrocyte differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oligodendrocyte development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within oligodendrocyte development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of myelination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of oligodendrocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 488
NP_001013799.2
XP_006519261.1
XP_036014633.1
XP_036014634.1
XP_036014635.1
XP_036014636.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013777.3 → NP_001013799.2  zinc finger protein 488

    See identical proteins and their annotated locations for NP_001013799.2

    Status: VALIDATED

    Source sequence(s)
    AC166828
    Consensus CDS
    CCDS26930.2
    UniProtKB/Swiss-Prot
    Q5HZG9
    Related
    ENSMUSP00000132436.2, ENSMUST00000166737.2
    Conserved Domains (1) summary
    sd00017
    Location:274 → 294
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    33689023..33700986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158743.1 → XP_036014636.1  zinc finger protein 488 isoform X2

    Conserved Domains (1) summary
    sd00017
    Location:312 → 332
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_006519198.5 → XP_006519261.1  zinc finger protein 488 isoform X3

    See identical proteins and their annotated locations for XP_006519261.1

    UniProtKB/Swiss-Prot
    Q5HZG9
    Conserved Domains (1) summary
    sd00017
    Location:274 → 294
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_036158741.1 → XP_036014634.1  zinc finger protein 488 isoform X1

    Conserved Domains (1) summary
    sd00017
    Location:318 → 338
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_036158740.1 → XP_036014633.1  zinc finger protein 488 isoform X1

    Conserved Domains (1) summary
    sd00017
    Location:318 → 338
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_036158742.1 → XP_036014635.1  zinc finger protein 488 isoform X2

    Conserved Domains (1) summary
    sd00017
    Location:312 → 332
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5HZG9.2 GenPept UniProtKB/Swiss-Prot:Q5HZG9

Gene LinkOut

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