oxt peptide O-xylosyltransferase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: oxtprovided by FlyBase
Official Full Name: peptide O-xylosyltransferaseprovided by FlyBase
Primary source: FLYBASE:FBgn0015360
Locus tag: Dmel_CG32300
See related: AllianceGenome:FB:FBgn0015360
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-i2; CG17771; CG17772; CG32300; Dmel\CG32300; dOXT; dXylT; Oxt; OXT
Summary: Enables protein xylosyltransferase activity. Involved in D-xylose metabolic process and proteoglycan metabolic process. Predicted to be located in membrane. Is expressed in adult head; organism; and spermatozoon. Human ortholog(s) of this gene implicated in Desbuquois dysplasia; pseudoxanthoma elasticum; and type 1 diabetes mellitus. Orthologous to several human genes including XYLT1 (xylosyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 62D4-62D4; 3-2 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (2258839..2262664, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (2258839..2262664, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional characterization of Drosophila melanogaster peptide O-xylosyltransferase
Title: Functional characterization of Drosophila melanogaster peptide O-xylosyltransferase, the key enzyme for proteoglycan chain initiation and member of the core 2/I N-acetylglucosaminyltransferase family.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein xylosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein xylosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein xylosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chondroitin sulfate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chondroitin sulfate proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chondroitin sulfate proteoglycan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in heparan sulfate proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparan sulfate proteoglycan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in heparan sulfate proteoglycan metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteoglycan biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: peptide O-xylosyltransferase

Names: CG32300-PB; O-xylosyltransferase; Peptide-O-xylosyl-transferase; Peptide-o-xylosyltransferase; drosophila peptide O-xylosyltransferase; oxt-PB

NP_647705.1

EC 2.4.-.-

EC 2.4.2.26

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

2258839..2262664 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_139448.4 → NP_647705.1 peptide O-xylosyltransferase [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_647705.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24116, Q7KVA1, Q9W034, Q9W035

Related

FBpp0072782

Conserved Domains (3) summary

pfam01822
Location:138 → 218

WSC; WSC domain

pfam02485
Location:250 → 503

Branch; Core-2/I-Branching enzyme

pfam12529
Location:537 → 710

Xylo_C; Xylosyltransferase C terminal