MsR2 Myosuppressin receptor 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: MsR2provided by FlyBase
Official Full Name: Myosuppressin receptor 2provided by FlyBase
Primary source: FLYBASE:FBgn0264002
Locus tag: Dmel_CG43745
See related: AllianceGenome:FB:FBgn0264002
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0170980.160; anon-WO0170980.161; CG13802; CG13803; CG43745; Dm CG13803; Dmel\CG43745; DMS R2; DMS-R2; DmsR; DmsR-2; DMSR-2; MS-R; Myo R2
Old locus tag: Dmel_CG13802; Dmel_CG13803
Summary: Enables myosuppressin receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; adult locomotory behavior; and behavioral defense response. Located in plasma membrane. Is expressed in VUM4 interneuron; VUM6 interneuron; crop; and ventral midline of embryo. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (2282883..2300944)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (2282883..2300944)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

DPKQDFMRFamide modulates both synaptic function and behavior through coincident detection mediated by FMRF receptor and dromyosuppressin receptor-2.
Title: Peptide-induced modulation of synaptic transmission and escape response in Drosophila requires two G-protein-coupled receptors.
molecular cloning and functional expression in cell lines of the myosuppressin receptor DMSR-2
Title: Molecular cloning and functional expression of the first two specific insect myosuppressin receptors.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled peptide receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables myosuppressin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables myosuppressin receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables neuropeptide receptor activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISM Inferred from Sequence Model more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

Names: CG43745-PA; CG43745-PB; CG43745-PC; DMS-receptor2; MsR2-PA; MsR2-PB; MsR2-PC; dromyosuppressin receptor 2

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The following sections contain reference sequences that belong to a specific genome build. Explain