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Svil Supervillin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38306, updated on 9-Dec-2024

Summary

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Official Symbol
Svilprovided by FlyBase
Official Full Name
Supervillinprovided by FlyBase
Primary source
FLYBASE:FBgn0266696
Locus tag
Dmel_CG45186
See related
AllianceGenome:FB:FBgn0266696
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
c62E-11; CG1141; CG12790; CG13797; CG13798; CG13799; CG13800; CG16763; CG16764; CG32306; CG33231; CG33232; CG42669; CG45186; Dmel\CG45186
Old locus tag
Dmel_CG13800; Dmel_CG32306; Dmel_CG33231; Dmel_CG33232; Dmel_CG42669
Summary
Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in several structures, including adult head; anlage in statu nascendi; central brain anlage in statu nascendi; dorsal ectoderm; and dorsal ectoderm anlage. Human ortholog(s) of this gene implicated in myofibrillar myopathy 10. Orthologous to human SVIL (supervillin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Svil in Genome Data Viewer
Location:
62D7-62E4; 3-3 cM
Exon count:
35
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2377655..2499226)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2377655..2499226)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L23 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mitotic spindle organizing protein 1 Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 4d20 Neighboring gene long non-coding RNA:CR45425 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The 62E early-late puff of Drosophila contains D-spinophilin, an ecdysone-inducible PDZ-domain protein dynamically expressed during metamorphosis. Keegan J, et al. Genet Res, 2001 Feb. PMID 11279828
  2. Mind bomb 2 promotes cell migration and epithelial structure by regulating adhesion complexes and the actin cytoskeleton. Trivedi S, et al. Dev Biol, 2022 Nov. PMID 36067835
  3. The genetic basis of variation in Drosophila melanogaster mating behavior. Yamamoto A, et al. iScience, 2024 May 17. PMID 38766354, Free PMC Article
  4. [LTR retrotransposons as a source of promoters in the Drosophila genome]. Makunin IV, et al. Genetika, 2010 Sep. PMID 21061618
  5. Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function. Muhammad K, et al. Nat Commun, 2015 Oct 16. PMID 26471740, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 2447560-2456657 mobile_element_type = transposon:roo{}911

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
supervillin
Names
CG45186-PA
CG45186-PAA
CG45186-PAB
CG45186-PAC
CG45186-PAD
CG45186-PAE
CG45186-PAF
CG45186-PAG
CG45186-PAH
CG45186-PC
CG45186-PE
CG45186-PF
CG45186-PG
CG45186-PH
CG45186-PJ
CG45186-PK
CG45186-PL
CG45186-PM
CG45186-PN
CG45186-PO
CG45186-PP
CG45186-PQ
CG45186-PR
CG45186-PS
CG45186-PT
CG45186-PU
CG45186-PV
CG45186-PW
CG45186-PX
CG45186-PY
CG45186-PZ
Svil-PA
Svil-PAA
Svil-PAB
Svil-PAC
Svil-PAD
Svil-PAE
Svil-PAF
Svil-PAG
Svil-PAH
Svil-PC
Svil-PE
Svil-PF
Svil-PG
Svil-PH
Svil-PJ
Svil-PK
Svil-PL
Svil-PM
Svil-PN
Svil-PO
Svil-PP
Svil-PQ
Svil-PR
Svil-PS
Svil-PT
Svil-PU
Svil-PV
Svil-PW
Svil-PX
Svil-PY
Svil-PZ
villin-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    2377655..2499226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274398.2 → NP_001261327.1  supervillin, isoform T [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261327.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQG5, Q7KV98

  2. NM_001299988.1 → NP_001286917.1  supervillin, isoform AC [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286917.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JCG0
    Conserved Domains (1) summary
    PRK11281
    Location:751 → 910
    PRK11281; hypothetical protein; Provisional

  3. NM_001202097.2 → NP_001189026.1  supervillin, isoform AH [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189026.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRN1
    Conserved Domains (2) summary
    PRK11281
    Location:751 → 910
    PRK11281; hypothetical protein; Provisional
    pfam06160
    Location:1607 → 1788
    EzrA; Septation ring formation regulator, EzrA

  4. NM_001299990.1 → NP_001286919.1  supervillin, isoform AE [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286919.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JAM4
    Conserved Domains (5) summary
    cd11280
    Location:3859 → 3965
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:4176 → 4279
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:3733 → 3825
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:4491 → 4526
    VHP; Villin headpiece domain
    cl15697
    Location:4069 → 4158
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  5. NM_001299987.1 → NP_001286916.1  supervillin, isoform AB [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286916.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JC02
    Conserved Domains (1) summary
    PRK11281
    Location:812 → 971
    PRK11281; hypothetical protein; Provisional

  6. NM_139462.4 → NP_647719.2  supervillin, isoform AF [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647719.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W018
    Conserved Domains (2) summary
    PRK11281
    Location:812 → 971
    PRK11281; hypothetical protein; Provisional
    pfam06160
    Location:1668 → 1849
    EzrA; Septation ring formation regulator, EzrA

  7. NM_001299989.1 → NP_001286918.1  supervillin, isoform AD [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286918.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J8M7
    Conserved Domains (1) summary
    PRK11281
    Location:751 → 910
    PRK11281; hypothetical protein; Provisional

  8. NM_001202098.2 → NP_001189027.1  supervillin, isoform AG [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189027.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRN1
    Conserved Domains (2) summary
    PRK11281
    Location:751 → 910
    PRK11281; hypothetical protein; Provisional
    pfam06160
    Location:1607 → 1788
    EzrA; Septation ring formation regulator, EzrA

  9. NM_001202101.1 → NP_001189030.1  supervillin, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189030.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQG5, Q7KV98

  10. NM_001202100.2 → NP_001189029.1  supervillin, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189029.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRP8

  11. NM_001169859.2 → NP_001163330.1  supervillin, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163330.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIC0

  12. NM_206242.3 → NP_995964.2  supervillin, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995964.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQG5, Q7KV98

  13. NM_001169858.2 → NP_001163329.1  supervillin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163329.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIB9, Q6NNW7

  14. NM_001259639.1 → NP_001246568.1  supervillin, isoform S [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246568.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NFH6

  15. NM_001259637.1 → NP_001246566.1  supervillin, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246566.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQG5, Q7KV98

  16. NM_001259638.1 → NP_001246567.1  supervillin, isoform R [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246567.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIB9, Q6NNW7

  17. NM_001274399.1 → NP_001261328.1  supervillin, isoform U [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261328.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDU5, Q6NNW7

  18. NM_001299986.1 → NP_001286915.1  supervillin, isoform W [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286915.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JG79
    Conserved Domains (5) summary
    cd11280
    Location:2373 → 2479
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:2690 → 2793
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:2247 → 2339
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:3006 → 3040
    VHP; Villin headpiece domain
    cl15697
    Location:2583 → 2672
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  19. NM_001202102.2 → NP_001189031.1  supervillin, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189031.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRN5

  20. NM_001202103.2 → NP_001189032.1  supervillin, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189032.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRZ4

  21. NM_139464.4 → NP_647721.3  supervillin, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647721.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQG5, Q9W016

  22. NM_001299985.1 → NP_001286914.1  supervillin, isoform V [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286914.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQG5, X2JAL9

  23. NM_001259636.1 → NP_001246565.1  supervillin, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246565.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C5WLV0, M9NEY0

  24. NM_001202104.2 → NP_001189033.2  supervillin, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189033.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRU6, Q960Y7

  25. NM_206246.3 → NP_995968.2  supervillin, isoform X [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995968.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8WHM3, Q7KV92
    Conserved Domains (5) summary
    cd11280
    Location:847 → 953
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:1164 → 1267
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:721 → 813
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:1480 → 1514
    VHP; Villin headpiece domain
    cl15697
    Location:1057 → 1146
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  26. NM_001202105.2 → NP_001189034.1  supervillin, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189034.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRQ1

  27. NM_167948.1 → NP_728744.1  supervillin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728744.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W013
    Related
    FBpp0311321, FBtr0345096

  28. NM_167949.1 → NP_728745.1  supervillin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728745.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IRF0
    Related
    FBpp0311320, FBtr0345095

  29. NM_001031933.3 → NP_001027104.1  supervillin, isoform Y [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027104.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8WHM3, Q0E8J1
    Conserved Domains (5) summary
    cd11280
    Location:489 → 595
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:806 → 909
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:363 → 455
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:1122 → 1156
    VHP; Villin headpiece domain
    cl15697
    Location:699 → 788
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  30. NM_206244.3 → NP_995966.1  supervillin, isoform Z [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995966.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8WHM3, Q0E8J1
    Conserved Domains (5) summary
    cd11280
    Location:489 → 595
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:806 → 909
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:363 → 455
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:1122 → 1156
    VHP; Villin headpiece domain
    cl15697
    Location:699 → 788
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

  31. NM_001274400.1 → NP_001261329.1  supervillin, isoform AA [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261329.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8WHM3, M9PEC5
    Conserved Domains (5) summary
    cd11280
    Location:444 → 550
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:761 → 864
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:318 → 410
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    pfam02209
    Location:1077 → 1111
    VHP; Villin headpiece domain
    cl15697
    Location:654 → 743
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JIB9 E1JIB9
E1JIC0 E1JIC0
M9MRN1 M9MRN1
M9MRN5 M9MRN5
M9MRP8 M9MRP8
M9MRQ1 M9MRQ1
M9MRU6 M9MRU6
M9MRZ4 M9MRZ4
M9NEY0 M9NEY0
M9NFH6 M9NFH6
M9PDU5 M9PDU5
M9PEC5 M9PEC5
Q0E8J1 Q0E8J1
Q7KV92 Q7KV92
Q7KV98 Q7KV98
Q8IRF0 Q8IRF0
Q95TG5 Q95TG5
Q960Y7 Q960Y7
Q9W013 Q9W013
Q9W016 Q9W016
Q9W018 Q9W018
X2J8M7 X2J8M7
X2JAL9 X2JAL9
X2JAM4 X2JAM4
X2JC02 X2JC02
X2JCG0 X2JCG0
X2JG79 X2JG79

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