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CG16758 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38315, updated on 4-Jan-2025

Summary

Official Symbol
CG16758provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0035348
Locus tag
Dmel_CG16758
See related
AllianceGenome:FB:FBgn0035348
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
c62E-15; CG16760; Dmel\CG16758
Summary
Predicted to enable purine-nucleoside phosphorylase activity. Involved in imaginal disc fusion, thorax closure. Predicted to be active in cytoplasm. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See CG16758 in Genome Data Viewer
Location:
62E4-62E4; 3-3 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2499372..2503606, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2499372..2503606, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Supervillin Neighboring gene Cytochrome P450 4d20 Neighboring gene long non-coding RNA:CR45425 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45170 Neighboring gene Spinophilin

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables purine-nucleoside phosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables purine-nucleoside phosphorylase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in imaginal disc fusion, thorax closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleoside metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
uncharacterized protein
Names
CG16758-PB
CG16758-PD
CG16758-PE
CG16758-PF
CG16758-PG
CG16758-PH
NP_001246569.1
NP_001261330.1
NP_647727.2
NP_728752.1
NP_995969.1
NP_995970.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    2499372..2503606 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167952.3NP_728752.1  uncharacterized protein Dmel_CG16758, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728752.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E4NKM8, Q9W004, Q9W005, Q9W006, Q9W007
    Related
    FBpp0072834
    Conserved Domains (2) summary
    COG0005
    Location:49324
    XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
    PRK08202
    Location:46324
    PRK08202; purine nucleoside phosphorylase; Provisional
  2. NM_139470.4NP_647727.2  uncharacterized protein Dmel_CG16758, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647727.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E4NKM8, Q7KV94
    Related
    FBpp0072833
    Conserved Domains (2) summary
    COG0005
    Location:73348
    XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
    PRK08202
    Location:70348
    PRK08202; purine nucleoside phosphorylase; Provisional
  3. NM_001259640.2NP_001246569.1  uncharacterized protein Dmel_CG16758, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246569.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E4NKM8, M9ND26
    Conserved Domains (2) summary
    COG0005
    Location:92367
    XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
    PRK08202
    Location:89367
    PRK08202; purine nucleoside phosphorylase; Provisional
  4. NM_001274401.1NP_001261330.1  uncharacterized protein Dmel_CG16758, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261330.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E4NKM8, M9PE19
    Conserved Domains (2) summary
    COG0005
    Location:116391
    XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
    PRK08202
    Location:113391
    PRK08202; purine nucleoside phosphorylase; Provisional
  5. NM_206247.2NP_995969.1  uncharacterized protein Dmel_CG16758, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995969.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E4NKM8, Q7KV95
    Conserved Domains (2) summary
    COG0005
    Location:48323
    XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
    PRK08202
    Location:45323
    PRK08202; purine nucleoside phosphorylase; Provisional
  6. NM_206248.2NP_995970.1  uncharacterized protein Dmel_CG16758, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995970.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E4NKM8, Q7KV91
    Conserved Domains (2) summary
    COG0005
    Location:41316
    XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
    PRK08202
    Location:38316
    PRK08202; purine nucleoside phosphorylase; Provisional