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Pxn Peroxidasin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38326, updated on 4-Jan-2025

Summary

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Official Symbol
Pxnprovided by FlyBase
Official Full Name
Peroxidasinprovided by FlyBase
Primary source
FLYBASE:FBgn0011828
Locus tag
Dmel_CG12002
See related
AllianceGenome:FB:FBgn0011828
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12002; CT1239; Dmel\CG12002; DmPxd-a; Dpxn; HPX4; pxn
Summary
Predicted to enable peroxidase activity. Involved in basement membrane assembly; collagen fibril organization; and phagocytosis. Predicted to be located in collagen-containing extracellular matrix. Predicted to be active in extracellular space. Is expressed in several structures, including adult brain; circulatory system primordium; embryonic/larval lymph gland; hemocyte; and somatic trunk mesoderm derivative. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 1; anterior segment dysgenesis 7; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to several human genes including PXDN (peroxidasin) and PXDNL (peroxidasin like). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Pxn in Genome Data Viewer
Location:
62E7-62E7; 3-3 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2601455..2630064, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2601455..2630064, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45981 Neighboring gene long non-coding RNA:CR45982 Neighboring gene long non-coding RNA:CR45660 Neighboring gene uncharacterized protein Neighboring gene MEP-1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Peroxidasin: a novel enzyme-matrix protein of Drosophila development. Nelson RE, et al. EMBO J, 1994 Aug 1. PMID 8062820, Free PMC Article
  2. Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults. Peebles KE, et al. Matrix Biol, 2024 Jan. PMID 38000777, Free PMC Article
  3. Circulating blood cells function as a surveillance system for damaged tissue in Drosophila larvae. Babcock DT, et al. Proc Natl Acad Sci U S A, 2008 Jul 22. PMID 18632567, Free PMC Article
  4. DSS-induced damage to basement membranes is repaired by matrix replacement and crosslinking. Howard AM, et al. J Cell Sci, 2019 Apr 8. PMID 30837285, Free PMC Article
  5. Bromine is an essential trace element for assembly of collagen IV scaffolds in tissue development and architecture. McCall AS, et al. Cell, 2014 Jun 5. PMID 24906154, Free PMC Article

See all (162) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults.
    Title: Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on peroxide as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in basement membrane assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in collagen fibril organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
peroxidasin
Names
CG12002-PA
CG12002-PB
CG12002-PC
CG12002-PD
CG12002-PE
Pxn-PA
Pxn-PB
Pxn-PC
Pxn-PD
Pxn-PE
peroxydasin
protein X
NP_523891.2
NP_728759.1
NP_995975.1
NP_995976.1
NP_995977.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    2601455..2630064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079167.5 → NP_523891.2  peroxidasin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523891.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23991, Q960D1, Q961K8, Q9VZZ4
    UniProtKB/TrEMBL
    D2NUH5, E0R979
    Related
    FBpp0072828
    Conserved Domains (11) summary
    cd00096
    Location:384 → 451
    Ig; Immunoglobulin domain
    cd09826
    Location:898 → 1338
    peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins
    smart00410
    Location:242 → 325
    IG_like; Immunoglobulin like
    cd00116
    Location:51 → 161
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:458 → 546
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:54 → 77
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00093
    Location:1465 → 1523
    VWC; von Willebrand factor type C domain
    pfam03098
    Location:777 → 1317
    An_peroxidase; Animal haem peroxidase
    pfam12799
    Location:148 → 185
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:55 → 112
    LRR_8; Leucine rich repeat
    cl11960
    Location:240 → 325
    Ig; Immunoglobulin domain

  2. NM_206255.3 → NP_995977.1  peroxidasin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995977.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23991, Q960D1, Q961K8, Q9VZZ4
    UniProtKB/TrEMBL
    D2NUH5, E0R979
    Conserved Domains (11) summary
    cd00096
    Location:384 → 451
    Ig; Immunoglobulin domain
    cd09826
    Location:898 → 1338
    peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins
    smart00410
    Location:242 → 325
    IG_like; Immunoglobulin like
    cd00116
    Location:51 → 161
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:458 → 546
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:54 → 77
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00093
    Location:1465 → 1523
    VWC; von Willebrand factor type C domain
    pfam03098
    Location:777 → 1317
    An_peroxidase; Animal haem peroxidase
    pfam12799
    Location:148 → 185
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:55 → 112
    LRR_8; Leucine rich repeat
    cl11960
    Location:240 → 325
    Ig; Immunoglobulin domain

  3. NM_206254.3 → NP_995976.1  peroxidasin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995976.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23991, Q960D1, Q961K8, Q9VZZ4
    UniProtKB/TrEMBL
    D2NUH5, E0R979
    Conserved Domains (11) summary
    cd00096
    Location:384 → 451
    Ig; Immunoglobulin domain
    cd09826
    Location:898 → 1338
    peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins
    smart00410
    Location:242 → 325
    IG_like; Immunoglobulin like
    cd00116
    Location:51 → 161
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:458 → 546
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:54 → 77
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00093
    Location:1465 → 1523
    VWC; von Willebrand factor type C domain
    pfam03098
    Location:777 → 1317
    An_peroxidase; Animal haem peroxidase
    pfam12799
    Location:148 → 185
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:55 → 112
    LRR_8; Leucine rich repeat
    cl11960
    Location:240 → 325
    Ig; Immunoglobulin domain

  4. NM_206253.3 → NP_995975.1  peroxidasin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995975.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23991, Q960D1, Q961K8, Q9VZZ4
    UniProtKB/TrEMBL
    D2NUH5, E0R979
    Conserved Domains (11) summary
    cd00096
    Location:384 → 451
    Ig; Immunoglobulin domain
    cd09826
    Location:898 → 1338
    peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins
    smart00410
    Location:242 → 325
    IG_like; Immunoglobulin like
    cd00116
    Location:51 → 161
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:458 → 546
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:54 → 77
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00093
    Location:1465 → 1523
    VWC; von Willebrand factor type C domain
    pfam03098
    Location:777 → 1317
    An_peroxidase; Animal haem peroxidase
    pfam12799
    Location:148 → 185
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:55 → 112
    LRR_8; Leucine rich repeat
    cl11960
    Location:240 → 325
    Ig; Immunoglobulin domain

  5. NM_167957.3 → NP_728759.1  peroxidasin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728759.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D5A7N1
    Related
    FBpp0072827
    Conserved Domains (8) summary
    cd00096
    Location:384 → 451
    Ig; Immunoglobulin domain
    smart00013
    Location:26 → 55
    LRRNT; Leucine rich repeat N-terminal domain
    smart00410
    Location:242 → 325
    IG_like; Immunoglobulin like
    cd00116
    Location:51 → 161
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:366 → 450
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:54 → 77
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:55 → 112
    LRR_8; Leucine rich repeat
    cl11960
    Location:240 → 325
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZZ4.1 Q9VZZ4

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