Kctd16 potassium channel tetramerisation domain containing 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kctd16provided by MGI
Official Full Name: potassium channel tetramerisation domain containing 16provided by MGI
Primary source: MGI:MGI:1914659
See related: Ensembl:ENSMUSG00000051401 AllianceGenome:MGI:1914659
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm1267; 2900055J20Rik; 4930434H12Rik; C030017B01Rik
Summary: Predicted to enable G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential and G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential. Acts upstream of or within regulation of G protein-coupled receptor signaling pathway. Located in postsynaptic membrane and presynaptic membrane. Part of receptor complex. Is expressed in autopod; central nervous system; dorsal root ganglion; sensory organ; and trachea. Orthologous to human KCTD16 (potassium channel tetramerization domain containing 16). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 6.6), cortex adult (RPKM 4.6) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B3; 18

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (40389358..40680311)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (40256305..40547258)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonstrated that the Kctd16(-/-) mice exhibited less extinction of auditory fear memory relative to WT and Kctd16(+/-) mice, as well as more contextual fear memory relative to WT and, in particular, Kctd16(+/-) mice.
Title: Behavioural endophenotypes in mice lacking the auxiliary GABA(B) receptor subunit KCTD16.
Data suggest that the distinct spatial and temporal distribution patterns of KCTD8, 12, 12b, and 16 underlie functional differences in native GABA(B) responses.
Title: Distribution of the auxiliary GABAB receptor subunits KCTD8, 12, 12b, and 16 in the mouse brain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MHAa54h2.seq (e-PCR)
- UniSTS:125226

14.MMHAP62FLE2.seq (e-PCR)
- UniSTS:123223

D18Mit227 (e-PCR), detects polymorphism
- UniSTS:128246

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: BTB/POZ domain-containing protein KCTD16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001371039.1 → NP_001357968.1 BTB/POZ domain-containing protein KCTD16

Status: VALIDATED

Source sequence(s)

AC098707, AC127249

Consensus CDS

CCDS50264.1

UniProtKB/Swiss-Prot

Q5DTY9, Q78Y50

Related

ENSMUSP00000158201.2, ENSMUST00000236889.2

Conserved Domains (1) summary

cd18398
Location:23 → 125

BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
NM_001371040.1 → NP_001357969.1 BTB/POZ domain-containing protein KCTD16

Status: VALIDATED

Source sequence(s)

AC098707, AC127249

Consensus CDS

CCDS50264.1

UniProtKB/Swiss-Prot

Q5DTY9, Q78Y50

Conserved Domains (1) summary

cd18398
Location:23 → 125

BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
NM_001371041.1 → NP_001357970.1 BTB/POZ domain-containing protein KCTD16

Status: VALIDATED

Source sequence(s)

AC098707, AC127249

Consensus CDS

CCDS50264.1

UniProtKB/Swiss-Prot

Q5DTY9, Q78Y50

Related

ENSMUSP00000089547.5, ENSMUST00000091927.5

Conserved Domains (1) summary

cd18398
Location:23 → 125

BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
NM_026135.2 → NP_080411.1 BTB/POZ domain-containing protein KCTD16

See identical proteins and their annotated locations for NP_080411.1

Status: VALIDATED

Source sequence(s)

AC098707, AC127249

Consensus CDS

CCDS50264.1

UniProtKB/Swiss-Prot

Q5DTY9, Q78Y50

Conserved Domains (1) summary

cd18398
Location:23 → 125

BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)