U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

AhcyL1 Adenosylhomocysteinase like 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38342, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
AhcyL1provided by FlyBase
Official Full Name
Adenosylhomocysteinase like 1provided by FlyBase
Primary source
FLYBASE:FBgn0035371
Locus tag
Dmel_CG9977
See related
AllianceGenome:FB:FBgn0035371
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9977; dAhcyL1; Dmel\CG9977; IRBIT
Summary
Involved in S-adenosylhomocysteine catabolic process. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic anal pad; embryonic/larval midgut; ganglia; and larval glial cell. Orthologous to human AHCYL1 (adenosylhomocysteinase like 1) and AHCYL2 (adenosylhomocysteinase like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See AhcyL1 in Genome Data Viewer
Location:
62F3-62F3; 3-4 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2768466..2772325, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2768466..2772325, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Myocardin-related transcription factor Neighboring gene Accessory gland protein 62F Neighboring gene Novel nucleolar protein 2 Neighboring gene uncharacterized protein Neighboring gene Autophagy-related 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. IRBIT Directs Differentiation of Intestinal Stem Cell Progeny to Maintain Tissue Homeostasis. Arnaoutov A, et al. iScience, 2020 Mar 27. PMID 32179478, Free PMC Article
  2. Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics - An AI-Enabled Biological Target Discovery Platform. Pun FW, et al. Front Aging Neurosci, 2022. PMID 35837482, Free PMC Article
  3. Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila. Parkhitko AA, et al. Genes Dev, 2016 Jun 15. PMID 27313316, Free PMC Article
  4. Ageing, metabolism and the intestine. Funk MC, et al. EMBO Rep, 2020 Jul 3. PMID 32567155, Free PMC Article
  5. Translational profiling of clock cells reveals circadianly synchronized protein synthesis. Huang Y, et al. PLoS Biol, 2013 Nov. PMID 24348200, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables adenosylhomocysteinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables adenosylhomocysteinase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in S-adenosylhomocysteine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in S-adenosylmethionine cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
adenosylhomocysteinase like 1
Names
AhcyL1-PA
CG9977-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    2768466..2772325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139489.2 → NP_647746.1  adenosylhomocysteinase like 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647746.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6NR07, Q9VZX9
    Related
    FBpp0072886
    Conserved Domains (1) summary
    pfam05221
    Location:94 → 520
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZX9.1 Q9VZX9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous