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Tet Ten-Eleven Translocation (TET) family protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38347, updated on 4-Jan-2025

Summary

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Official Symbol
Tetprovided by FlyBase
Official Full Name
Ten-Eleven Translocation (TET) family proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0263392
Locus tag
Dmel_CG43444
See related
AllianceGenome:FB:FBgn0263392
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2083; CG43444; CG9973; DMAD; Dmel\CG43444; DNA 6mA; dTet; dTET; Idax; TET
Old locus tag
Dmel_CG2083; Dmel_CG9973
Summary
Enables broad specificity oxidative DNA demethylase activity. Involved in several processes, including DNA modification; germ cell development; and transposable element silencing. Located in nucleus. Is expressed in several structures, including antennal anlage; ganglia; germline cell; head epidermis primordium; and larval imaginal tissue. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to several human genes including TET3 (tet methylcytosine dioxygenase 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Tet in Genome Data Viewer
Location:
62F4-63A1; 3-4 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2786207..2879158, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2786207..2879158, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S35 Neighboring gene Polypeptide N-Acetylgalactosaminyltransferase 6 Neighboring gene long non-coding RNA:CR44531 Neighboring gene spatzle 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNA N(6)-methyladenine: a new epigenetic mark in eukaryotes? Luo GZ, et al. Nat Rev Mol Cell Biol, 2015 Dec. PMID 26507168, Free PMC Article
  2. Adenine Methylation in Drosophila Is Associated with the Tissue-Specific Expression of Developmental and Regulatory Genes. Shah K, et al. G3 (Bethesda), 2019 Jun 5. PMID 30988038, Free PMC Article
  3. Drosophila Tet Is Required for Maintaining Glial Homeostasis in Developing and Adult Fly Brains. Frey F, et al. eNeuro, 2022 Mar-Apr. PMID 35396259, Free PMC Article
  4. Adenine methylation is very scarce in the Drosophila genome and not erased by the ten-eleven translocation dioxygenase. Boulet M, et al. Elife, 2023 Dec 21. PMID 38126351, Free PMC Article
  5. The mysterious presence of a 5-methylcytosine oxidase in the Drosophila genome: possible explanations. Dunwell TL, et al. Cell Cycle, 2013 Nov 1. PMID 24091536, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila TET acts with PRC1 to activate gene expression independently of its catalytic activity.
    Title: Drosophila TET acts with PRC1 to activate gene expression independently of its catalytic activity.
  2. Niche Tet maintains germline stem cells independently of dioxygenase activity.
    Title: Niche Tet maintains germline stem cells independently of dioxygenase activity.
  3. Tet-dependent 5-hydroxymethyl-Cytosine modification of mRNA regulates axon guidance genes in Drosophila.
    Title: Tet-dependent 5-hydroxymethyl-Cytosine modification of mRNA regulates axon guidance genes in Drosophila.
  4. Adenine methylation is very scarce in the Drosophila genome and not erased by the ten-eleven translocation dioxygenase.
    Title: Adenine methylation is very scarce in the Drosophila genome and not erased by the ten-eleven translocation dioxygenase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 5-methylcytosine dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5-methylcytosine dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables broad specificity oxidative DNA demethylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in RNA modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosomal 5-methylcytosine DNA demethylation pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transposable element silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Ten-Eleven translocation (TET) family protein
Names
CG43444-PA
CG43444-PB
CG43444-PC
CG43444-PD
CG43444-PE
CG43444-PF
DNA 6mA demethylase
TET family protein
Tet-PA
Tet-PB
Tet-PC
Tet-PD
Tet-PE
Tet-PF
NP_001246581.1
NP_001246582.1
NP_001246583.1
NP_001261343.1
NP_001261344.1
NP_647750.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    2786207..2879158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259652.2 → NP_001246581.1  Ten-Eleven translocation (TET) family protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246581.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9NDF7, M9NEY8, M9PDW4, M9PEE3, Q8T0I1, Q8T9G4, Q9VZX4
    Conserved Domains (2) summary
    pfam02008
    Location:590 → 630
    zf-CXXC; CXXC zinc finger domain
    pfam12851
    Location:1796 → 1929
    Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily

  2. NM_001274414.2 → NP_001261343.1  Ten-Eleven translocation (TET) family protein, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261343.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9NEY8
    Conserved Domains (2) summary
    pfam02008
    Location:590 → 630
    zf-CXXC; CXXC zinc finger domain
    pfam12851
    Location:1802 → 1935
    Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily

  3. NM_001259654.2 → NP_001246583.1  Ten-Eleven translocation (TET) family protein, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246583.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9NEY8
    Conserved Domains (1) summary
    pfam12851
    Location:992 → 1125
    Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily

  4. NM_001259653.1 → NP_001246582.1  Ten-Eleven translocation (TET) family protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246582.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9NEY8
    Conserved Domains (2) summary
    pfam02008
    Location:646 → 686
    zf-CXXC; CXXC zinc finger domain
    pfam12851
    Location:1851 → 1984
    Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily

  5. NM_001274415.1 → NP_001261344.1  Ten-Eleven translocation (TET) family protein, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261344.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9NEY8
    Conserved Domains (2) summary
    pfam02008
    Location:646 → 686
    zf-CXXC; CXXC zinc finger domain
    pfam12851
    Location:1857 → 1990
    Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily

  6. NM_139493.4 → NP_647750.4  Ten-Eleven translocation (TET) family protein, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647750.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9NEY8
    Conserved Domains (1) summary
    pfam12851
    Location:992 → 1125
    Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NEY8.1 M9NEY8
Q95SH6 Q95SH6

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