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PAN3 Poly(A) specific ribonuclease subunit PAN3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38369, updated on 9-Dec-2024

Summary

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Official Symbol
PAN3provided by FlyBase
Official Full Name
Poly(A) specific ribonuclease subunit PAN3provided by FlyBase
Primary source
FLYBASE:FBgn0035397
Locus tag
Dmel_CG11486
See related
AllianceGenome:FB:FBgn0035397
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11486; Dmel\CG11486; pan3; Pan3
Summary
Predicted to enable poly(A) binding activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Located in cytoplasm. Is expressed in adult brain; adult brain cell body rind; organism; and spermatozoon. Orthologous to human PAN3 (poly(A) specific ribonuclease subunit PAN3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See PAN3 in Genome Data Viewer
Location:
63A6-63B1; 3-5 cM
Exon count:
20
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3071133..3090406)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3071133..3090406)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene small nuclear RNA U5 at 63BC Neighboring gene transfer RNA:Cysteine-GCA 1-1 Neighboring gene Chitinase 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-Wide Responses of Female Fruit Flies Subjected to Divergent Mating Regimes. Gerrard DT, et al. PLoS One, 2013. PMID 23826372, Free PMC Article
  2. HELZ directly interacts with CCR4-NOT and causes decay of bound mRNAs. Hanet A, et al. Life Sci Alliance, 2019 Oct. PMID 31570513, Free PMC Article
  3. Distinct modes of recruitment of the CCR4-NOT complex by Drosophila and vertebrate Nanos. Raisch T, et al. EMBO J, 2016 May 2. PMID 26968986, Free PMC Article
  4. A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin. Sgromo A, et al. Nat Commun, 2017 Feb 6. PMID 28165457, Free PMC Article
  5. The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets. Huntzinger E, et al. Nucleic Acids Res, 2013 Jan. PMID 23172285, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
NOT enables protein kinase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA poly(A) tail shortening IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PAN complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PAN complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 

General protein information

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Preferred Names
Poly(A) specific ribonuclease subunit PAN3
Names
CG11486-PA
CG11486-PB
CG11486-PC
CG11486-PD
CG11486-PF
CG11486-PG
CG11486-PH
CG11486-PJ
CG11486-PK
CG11486-PL
CG11486-PM
CG11486-PN
CG11486-PO
CG11486-PP
CG11486-PQ
CG11486-PR
PAN3-PA
PAN3-PB
PAN3-PC
PAN3-PD
PAN3-PF
PAN3-PG
PAN3-PH
PAN3-PJ
PAN3-PK
PAN3-PL
PAN3-PM
PAN3-PN
PAN3-PO
PAN3-PP
PAN3-PQ
PAN3-PR
polyA-nuclease related

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3071133..3090406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167977.3 → NP_728799.1  Poly(A) specific ribonuclease subunit PAN3, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728799.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMN9, Q7KV83
    Related
    FBpp0072870
    Conserved Domains (2) summary
    cd00180
    Location:404 → 568
    PKc; Catalytic domain of Protein Kinases
    pfam16051
    Location:243 → 282
    DUF4797; Domain of unknown function (DUF4797)

  2. NM_167976.3 → NP_728798.1  Poly(A) specific ribonuclease subunit PAN3, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728798.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMN9, Q7KV83
    Related
    FBpp0072868
    Conserved Domains (2) summary
    cd00180
    Location:404 → 568
    PKc; Catalytic domain of Protein Kinases
    pfam16051
    Location:243 → 282
    DUF4797; Domain of unknown function (DUF4797)

  3. NM_139510.4 → NP_647767.1  Poly(A) specific ribonuclease subunit PAN3, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647767.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95RR8
    UniProtKB/TrEMBL
    D3DMN9
    Related
    FBpp0072861
    Conserved Domains (2) summary
    cd00180
    Location:406 → 570
    PKc; Catalytic domain of Protein Kinases
    pfam16051
    Location:245 → 284
    DUF4797; Domain of unknown function (DUF4797)

  4. NM_001104017.2 → NP_001097487.1  Poly(A) specific ribonuclease subunit PAN3, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097487.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMN9, Q8IRE7
    Conserved Domains (2) summary
    cd00180
    Location:373 → 537
    PKc; Catalytic domain of Protein Kinases
    pfam16051
    Location:212 → 251
    DUF4797; Domain of unknown function (DUF4797)

  5. NM_206261.3 → NP_995983.1  Poly(A) specific ribonuclease subunit PAN3, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995983.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMN9, Q7KV83
    Conserved Domains (2) summary
    cd00180
    Location:404 → 568
    PKc; Catalytic domain of Protein Kinases
    pfam16051
    Location:243 → 282
    DUF4797; Domain of unknown function (DUF4797)

  6. NM_206260.3 → NP_995982.1  Poly(A) specific ribonuclease subunit PAN3, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995982.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMN9, Q7KV83
    Conserved Domains (2) summary
    cd00180
    Location:404 → 568
    PKc; Catalytic domain of Protein Kinases
    pfam16051
    Location:243 → 282
    DUF4797; Domain of unknown function (DUF4797)

  7. NM_167979.3 → NP_728801.1  Poly(A) specific ribonuclease subunit PAN3, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728801.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMN9, Q8IRE7
    Related
    FBpp0072869
    Conserved Domains (2) summary
    cd00180
    Location:373 → 537
    PKc; Catalytic domain of Protein Kinases
    pfam16051
    Location:212 → 251
    DUF4797; Domain of unknown function (DUF4797)

  8. NM_001104018.2 → NP_001097488.1  Poly(A) specific ribonuclease subunit PAN3, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097488.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMN9, Q7KV83
    Conserved Domains (2) summary
    cd00180
    Location:404 → 568
    PKc; Catalytic domain of Protein Kinases
    pfam16051
    Location:243 → 282
    DUF4797; Domain of unknown function (DUF4797)

  9. NM_167978.3 → NP_728800.1  Poly(A) specific ribonuclease subunit PAN3, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728800.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMN9, Q7KV83
    Related
    FBpp0072871
    Conserved Domains (2) summary
    cd00180
    Location:404 → 568
    PKc; Catalytic domain of Protein Kinases
    pfam16051
    Location:243 → 282
    DUF4797; Domain of unknown function (DUF4797)

  10. NM_167975.3 → NP_728797.1  Poly(A) specific ribonuclease subunit PAN3, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728797.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMN9, Q7KV83
    Related
    FBpp0072862
    Conserved Domains (2) summary
    cd00180
    Location:404 → 568
    PKc; Catalytic domain of Protein Kinases
    pfam16051
    Location:243 → 282
    DUF4797; Domain of unknown function (DUF4797)

  11. NM_167981.2 → NP_728803.2  Poly(A) specific ribonuclease subunit PAN3, isoform R [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728803.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMN9, Q8IRE7
    Conserved Domains (2) summary
    cd00180
    Location:373 → 537
    PKc; Catalytic domain of Protein Kinases
    pfam16051
    Location:212 → 251
    DUF4797; Domain of unknown function (DUF4797)

  12. NM_167980.3 → NP_728802.2  Poly(A) specific ribonuclease subunit PAN3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728802.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMN9, Q9VZV3
    Related
    FBpp0072864
    Conserved Domains (2) summary
    cd00180
    Location:396 → 560
    PKc; Catalytic domain of Protein Kinases
    pfam16051
    Location:235 → 274
    DUF4797; Domain of unknown function (DUF4797)

  13. NM_167983.3 → NP_728805.1  Poly(A) specific ribonuclease subunit PAN3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728805.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMN9, Q9I7T8
    Related
    FBpp0072863
    Conserved Domains (2) summary
    cd00180
    Location:358 → 522
    PKc; Catalytic domain of Protein Kinases
    pfam16051
    Location:197 → 236
    DUF4797; Domain of unknown function (DUF4797)

  14. NM_001104016.2 → NP_001097486.1  Poly(A) specific ribonuclease subunit PAN3, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097486.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNJ2, D3DMN9
    Conserved Domains (2) summary
    cd00180
    Location:365 → 529
    PKc; Catalytic domain of Protein Kinases
    pfam16051
    Location:204 → 243
    DUF4797; Domain of unknown function (DUF4797)

  15. NM_167984.3 → NP_728806.1  Poly(A) specific ribonuclease subunit PAN3, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728806.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMN9, Q9I7T8
    Related
    FBpp0072865
    Conserved Domains (2) summary
    cd00180
    Location:358 → 522
    PKc; Catalytic domain of Protein Kinases
    pfam16051
    Location:197 → 236
    DUF4797; Domain of unknown function (DUF4797)

  16. NM_167982.3 → NP_728804.1  Poly(A) specific ribonuclease subunit PAN3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728804.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMN9, Q9I7T8
    Related
    FBpp0072866
    Conserved Domains (2) summary
    cd00180
    Location:358 → 522
    PKc; Catalytic domain of Protein Kinases
    pfam16051
    Location:197 → 236
    DUF4797; Domain of unknown function (DUF4797)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JNJ2 A8JNJ2
Q7KV83 Q7KV83
Q8IRE7 Q8IRE7
Q95RR8.1 Q95RR8
Q9I7T8 Q9I7T8
Q9VZV3 Q9VZV3

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