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CG12016 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38411, updated on 9-Dec-2024

Summary

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Official Symbol
CG12016provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0035436
Locus tag
Dmel_CG12016
See related
AllianceGenome:FB:FBgn0035436
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG12016; dNrk; Dromel_CG12016_FBtr0073063_mORF
Summary
Predicted to enable ribosylnicotinamide kinase activity. Predicted to be involved in nicotinamide riboside metabolic process. Predicted to be active in cytoplasm. Is expressed in organism. Orthologous to several human genes including NMRK2 (nicotinamide riboside kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG12016 in Genome Data Viewer
Location:
63D1-63D1; 3-8 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3319555..3322489)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3319555..3322489)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Drosomycin-like 5 Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class C Neighboring gene Dolichyl-phosphate mannosyltransferase subunit 2 Neighboring gene Striatin interacting protein Neighboring gene Glutathione peroxidase homolog with thioredoxin peroxidase activity Neighboring gene long non-coding RNA:CR45380

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The NAD(+) precursor NMN activates dSarm to trigger axon degeneration in Drosophila. Llobet Rosell A, et al. Elife, 2022 Dec 23. PMID 36476387, Free PMC Article
  2. Drosophila Strip serves as a platform for early endosome organization during axon elongation. Sakuma C, et al. Nat Commun, 2014 Oct 14. PMID 25312435, Free PMC Article
  3. Exhaustive identification of conserved upstream open reading frames with potential translational regulatory functions from animal genomes. Takahashi H, et al. Sci Rep, 2020 Oct 1. PMID 33004976, Free PMC Article
  4. Comparative genomic analysis of novel conserved peptide upstream open reading frames in Drosophila melanogaster and other dipteran species. Hayden CA, et al. BMC Genomics, 2008 Feb 1. PMID 18237443, Free PMC Article
  5. Comparative transcriptomic analysis of human and Drosophila extracellular vesicles. Lefebvre FA, et al. Sci Rep, 2016 Jun 10. PMID 27282340, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ribosylnicotinamide kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosylnicotinamide kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in nicotinamide riboside metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG12016-PA
CG12016-PB
NP_647805.1
NP_728865.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3319555..3322489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139548.4 → NP_647805.1  uncharacterized protein Dmel_CG12016, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647805.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SV2, Q9VZR0
    Related
    FBpp0072927
    Conserved Domains (1) summary
    cd02024
    Location:6 → 255
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

  2. NM_168022.2 → NP_728865.1  uncharacterized protein Dmel_CG12016, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728865.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95SV2, Q9VZR0
    Related
    FBpp0072928
    Conserved Domains (1) summary
    cd02024
    Location:6 → 255
    NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZR0 Q9VZR0

Gene LinkOut

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