Gtpx - Glutathione peroxidase homolog with thioredoxin peroxidase activity

Enables thioredoxin-dependent peroxiredoxin activity. Involved in intestinal stem cell homeostasis; response to endoplasmic reticulum stress; and response to oxidative stress. Located in Golgi apparatus. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic/larval fat body; and germline cell. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4). [provided by Alliance of Genome Resources, Dec 2024]

NCBI Orthologs

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