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ntc nutcracker [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38443, updated on 4-Jan-2025

Summary

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Official Symbol
ntcprovided by FlyBase
Official Full Name
nutcrackerprovided by FlyBase
Primary source
FLYBASE:FBgn0035461
Locus tag
Dmel_CG10855
See related
AllianceGenome:FB:FBgn0035461
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10855; Dmel\CG10855; FBXO7
Summary
Enables cysteine-type endopeptidase activator activity involved in apoptotic process. Involved in several processes, including positive regulation of mitophagy; protein stabilization; and sperm individualization. Part of SCF ubiquitin ligase complex. Is expressed in cystic bulge and organism. Used to study Parkinson's disease 15. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See ntc in Genome Data Viewer
Location:
63F1-63F1; 3-9 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3803832..3806459, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3803832..3806459, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pickpocket 27 Neighboring gene uncharacterized protein Neighboring gene Integrator 10 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel. Frochaux MV, et al. Genome Biol, 2020 Jan 17. PMID 31948474, Free PMC Article
  2. Drosophila Skp1 Homologue SkpA Plays a Neuroprotective Role in Adult Brain. Dabool L, et al. iScience, 2020 Aug 21. PMID 32739834, Free PMC Article
  3. The FBXO7 homologue nutcracker and binding partner PI31 in Drosophila melanogaster models of Parkinson's disease. Merzetti EM, et al. Genome, 2017 Jan. PMID 27936908
  4. FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivo. Sanchez-Martinez A, et al. PLoS Biol, 2023 Aug. PMID 37535686, Free PMC Article
  5. A conserved F box regulatory complex controls proteasome activity in Drosophila. Bader M, et al. Cell, 2011 Apr 29. PMID 21529711, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ubiquitin-like ligase-substrate adaptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
Inferred from Sequence Model
more info
  
involved_in positive regulation of mitophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm individualization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SCF ubiquitin ligase complex ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
nutcracker
Names
CG10855-PA
ntc-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3803832..3806459 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139572.3 → NP_647829.1  nutcracker [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647829.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SX86, Q9VZM8
    Related
    FBpp0073041
    Conserved Domains (1) summary
    pfam00646
    Location:265 → 310
    F-box; F-box domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SX86.1 Q8SX86

Gene LinkOut

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