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Ubi-p63E Ubiquitin-63E [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38456, updated on 9-Dec-2024

Summary

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Official Symbol
Ubi-p63Eprovided by FlyBase
Official Full Name
Ubiquitin-63Eprovided by FlyBase
Primary source
FLYBASE:FBgn0003943
Locus tag
Dmel_CG11624
See related
AllianceGenome:FB:FBgn0003943
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11624; Dmel\CG11624; DmUb; DmUbi-p63E; magn; Ub; UB; Ub-p63E; ubi; Ubi-p; ubi-p63E; Ubi-P63e; ubi63E; Ubi63E; Ubi63p; Ubip; Ubip63E; Ubiq; Ubp
Summary
Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Involved in larval midgut cell programmed cell death and macroautophagy. Predicted to be active in cytoplasm and nucleus. Is expressed in spermatocyte. Orthologous to human UBC (ubiquitin C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ubi-p63E in Genome Data Viewer
Location:
63F5-63F5; 3-9 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3899259..3903184, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3899259..3903184, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 63a Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 Neighboring gene Caffeine, calcium, zinc sensitivity 1 Neighboring gene Sc2 Neighboring gene imaginal discs arrested

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Localization and expression of transformed DNA sequences within heat shock puffs of Drosophila melanogaster. Simon JA, et al. Chromosoma, 1985. PMID 3933923
  2. Puffing patterns in Drosophila melanogaster and related species. Ashburner M. Results Probl Cell Differ, 1972. PMID 4198830
  3. Cloning and characterization of nine heat-shock-induced mRNAs of Drosophila melanogaster. Lis JT, et al. Gene, 1981 Oct. PMID 6795091
  4. Polyubiquitin-regulated DsRed marker for transgenic insects. Handler AM, et al. Biotechniques, 2001 Oct. PMID 11680713
  5. Distinct responses to rare codons in select Drosophila tissues. Allen SR, et al. Elife, 2022 May 6. PMID 35522036, Free PMC Article

See all (332) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results showed the molecular cloning UB and L40 genes from Drosophila kc cells and the first evidence that both of them play roles in the regulation of deltamethrin resistance.
    Title: Analysis of UB and L40 resistance related to deltamethrin in Drosophila kc cells.
  2. The polyubiquitin gene Ubi-p63E is essential for male meiotic cell cycle progression and germ cell differentiation in Drosophila.
    Title: The polyubiquitin gene Ubi-p63E is essential for male meiotic cell cycle progression and germ cell differentiation in Drosophila.
  3. Ubiquitylation of p54
    Title: Ubiquitylation of Drosophila p54/Rpn10/S5a regulates its interaction with the UBA-UBL polyubiquitin receptors.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein tag activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tag activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in larval midgut cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in modification-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ubiquitin-63E
Names
CG11624-PA
CG11624-PB
CG11624-PC
CG11624-PD
Ubi-p63E-PA
Ubi-p63E-PB
Ubi-p63E-PC
Ubi-p63E-PD
Ubiquitin-63-E
Ubiquitin-polymeric
magellan
polyubiquitin
ubiquitin
ubiquitin 63E
ubiquitin-63E

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3899259..3903184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079185.4 → NP_523909.2  Ubiquitin-63E, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523909.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P0CG69
    UniProtKB/TrEMBL
    A4V1F9
    Related
    FBpp0073035, FBtr0073178
    Conserved Domains (1) summary
    cd01803
    Location:77 → 152
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin

  2. NM_001274454.1 → NP_001261383.1  Ubiquitin-63E, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261383.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P0CG69
    UniProtKB/TrEMBL
    A4V1F9
    Conserved Domains (1) summary
    cd01803
    Location:77 → 152
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin

  3. NM_206272.1 → NP_995994.1  Ubiquitin-63E, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995994.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P0CG69
    UniProtKB/TrEMBL
    A4V1F9
    Conserved Domains (1) summary
    cd01803
    Location:77 → 152
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin

  4. NM_168043.3 → NP_728908.1  Ubiquitin-63E, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728908.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P0CG69
    UniProtKB/TrEMBL
    A4V1F9
    Related
    FBpp0073034
    Conserved Domains (1) summary
    cd01803
    Location:77 → 152
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V1F9 A4V1F9
P0CG69.1 P0CG69
Q24575 Q24575
Q24576 Q24576
Q24577 Q24577
Q27927 Q27927
Q7JPZ2 Q7JPZ2
Q7JPZ3 Q7JPZ3
Q8MSM5 Q8MSM5
Q99347 Q99347
Q99348 Q99348
Q99349 Q99349
Q99350 Q99350
Q99351 Q99351

Gene LinkOut

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