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CG12766 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38462, updated on 9-Dec-2024

Summary

Official Symbol
CG12766provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0035476
Locus tag
Dmel_CG12766
See related
AllianceGenome:FB:FBgn0035476
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG12766
Summary
Predicted to enable aldose reductase (NADPH) activity. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8. Orthologous to human AKR1B10 (aldo-keto reductase family 1 member B10); AKR1B15 (aldo-keto reductase family 1 member B15); and AKR1C4 (aldo-keto reductase family 1 member C4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See CG12766 in Genome Data Viewer
Location:
64A1-64A1; 3-10 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3938624..3940125, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3938624..3940125, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ecdysone-induced protein 63F 1 Neighboring gene antisense RNA:Ecdysone-induced gene 63F 2 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43916 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables aldose reductase (NADPH) activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
uncharacterized protein
Names
CG12766-PA
NP_647839.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3938624..3940125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139582.3NP_647839.1  uncharacterized protein Dmel_CG12766 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647839.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZK8
    Related
    FBpp0073029
    Conserved Domains (2) summary
    COG0656
    Location:5298
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:12299
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]