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CG12605 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38468, updated on 9-Dec-2024

Summary

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Official Symbol
CG12605provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0035481
Locus tag
Dmel_CG12605
See related
AllianceGenome:FB:FBgn0035481
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.93; Dmel\CG12605
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Orthologous to human SCRT1 (scratch family transcriptional repressor 1) and SCRT2 (scratch family transcriptional repressor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG12605 in Genome Data Viewer
Location:
64A1-64A1; 3-10 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3954251..3964771, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3954251..3964771, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene scratch

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Selective maintenance of Drosophila tandemly arranged duplicated genes during evolution. Quijano C, et al. Genome Biol, 2008. PMID 19087263, Free PMC Article
  2. Systematic identification and characterization of repressive domains in Drosophila transcription factors. Klaus L, et al. EMBO J, 2023 Feb 1. PMID 36545802, Free PMC Article
  3. Synergistic activation by Glass and Pointed promotes neuronal identity in the Drosophila eye disc. Wang H, et al. Nat Commun, 2024 Aug 17. PMID 39154080, Free PMC Article
  4. Pervasive variation of transcription factor orthologs contributes to regulatory network evolution. Nadimpalli S, et al. PLoS Genet, 2015 Mar. PMID 25748510, Free PMC Article
  5. Analysis of the eye developmental pathway in Drosophila using DNA microarrays. Michaut L, et al. Proc Natl Acad Sci U S A, 2003 Apr 1. PMID 12655063, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear body ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG12605-PA
CG12605-PB
CG12605-PC
CG12605-PD
CG12605-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3954251..3964771 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274458.1 → NP_001261387.1  uncharacterized protein Dmel_CG12605, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261387.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29R14, Q8SZN0
    Conserved Domains (5) summary
    COG5048
    Location:492 → 570
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:498 → 518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:441 → 461
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:524 → 546
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:511 → 534
    zf-H2C2_2; Zinc-finger double domain

  2. NM_206275.3 → NP_995997.1  uncharacterized protein Dmel_CG12605, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995997.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29R14, Q8SZN0
    Conserved Domains (5) summary
    COG5048
    Location:492 → 570
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:498 → 518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:441 → 461
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:524 → 546
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:511 → 534
    zf-H2C2_2; Zinc-finger double domain

  3. NM_206274.3 → NP_995996.1  uncharacterized protein Dmel_CG12605, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995996.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D2NUG4, Q7KV66
    Conserved Domains (5) summary
    COG5048
    Location:347 → 425
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:353 → 373
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:296 → 316
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:379 → 401
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:366 → 389
    zf-H2C2_2; Zinc-finger double domain

  4. NM_139588.4 → NP_647845.2  uncharacterized protein Dmel_CG12605, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647845.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29R14, Q8SZN0
    Related
    FBpp0073023
    Conserved Domains (5) summary
    COG5048
    Location:492 → 570
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:498 → 518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:441 → 461
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:524 → 546
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:511 → 534
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001274459.1 → NP_001261388.1  uncharacterized protein Dmel_CG12605, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261388.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29R14, Q8SZN0
    Conserved Domains (5) summary
    COG5048
    Location:492 → 570
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:498 → 518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:441 → 461
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:524 → 546
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:511 → 534
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q29R14 Q29R14
Q7KV66 Q7KV66
Q8SZN0 Q8SZN0

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