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Gad1 Glutamic acid decarboxylase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38484, updated on 4-Jan-2025

Summary

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Official Symbol
Gad1provided by FlyBase
Official Full Name
Glutamic acid decarboxylase 1provided by FlyBase
Primary source
FLYBASE:FBgn0004516
Locus tag
Dmel_CG14994
See related
AllianceGenome:FB:FBgn0004516
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14994; dgad1; dGad1; DGad1; DGAD1; Dm-GDC; Dmel\CG14994; gad; Gad; GAD; GAD-1; gad1; GAD1; GAD[[1]]; Glb; l(3)64An; l(3)SH10
Summary
Enables glutamate decarboxylase activity. Involved in several processes, including carboxylic acid metabolic process; olfactory learning; and synapse organization. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; brain; ellipsoid body layer; neurons; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; amphetamine abuse; developmental and epileptic encephalopathy 89; diabetes mellitus (multiple); and drug psychosis. Orthologous to human GAD1 (glutamate decarboxylase 1) and GAD2 (glutamate decarboxylase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Gad1 in Genome Data Viewer
Location:
64A5-64A5; 3-10 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4074077..4088744, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4074077..4088744, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene wishful thinking Neighboring gene uncharacterized protein Neighboring gene Fumarylacetoacetase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fermitin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional organization of a Drosophila glutamic acid decarboxylase gene. Newby LM, et al. J Neurochem, 1993 Mar. PMID 8436982
  2. The GABAergic anterior paired lateral neuron suppresses and is suppressed by olfactory learning. Liu X, et al. Nat Neurosci, 2009 Jan. PMID 19043409, Free PMC Article
  3. Decoding odor quality and intensity in the Drosophila brain. Strutz A, et al. Elife, 2014 Dec 16. PMID 25512254, Free PMC Article
  4. An examination of aspartate decarboxylase and glutamate decarboxylase activity in mosquitoes. Richardson G, et al. Mol Biol Rep, 2010 Oct. PMID 19842059, Free PMC Article
  5. Aneuploidy is Linked to Neurological Phenotypes Through Oxidative Stress. Islam A, et al. J Mol Neurosci, 2024 May 2. PMID 38693434, Free PMC Article

See all (197) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TDP-43 regulates GAD1 mRNA splicing and GABA signaling in Drosophila CNS.
    Title: TDP-43 regulates GAD1 mRNA splicing and GABA signaling in Drosophila CNS.
  2. Negative developmental regulation of GAD can be overridden by drugs known to elevate intracellular free [Ca2+]
    Title: In developing Drosophila neurones the production of gamma-amino butyric acid is tightly regulated downstream of glutamate decarboxylase translation and can be influenced by calcium.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamate decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamate decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamate decarboxylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables glutamate decarboxylase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in gamma-aminobutyric acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gamma-aminobutyric acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gamma-aminobutyric acid biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in glutamate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in olfactory learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to mechanical stimulus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol HDA PubMed 

General protein information

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Preferred Names
glutamic acid decarboxylase 1
Names
CG14994-PA
CG14994-PB
CG14994-PC
CG14994-PD
GABA synthetase
Gad1-PA
Gad1-PB
Gad1-PC
Gad1-PD
glutamate decarboxylase
glutamatic acid decarboxylase
glutamic acid decarboxylase
glutamic acid decarboxylase-1
vesicular glutamic acid decarboxylase
NP_001261396.1
NP_523914.2
NP_728930.1
NP_728931.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4074077..4088744 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168055.2 → NP_728930.1  glutamic acid decarboxylase 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728930.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1G1, P20228, Q9VZI7
    UniProtKB/TrEMBL
    M9PH99
    Related
    FBpp0073131
    Conserved Domains (1) summary
    pfam00282
    Location:64 → 434
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

  2. NM_001274467.1 → NP_001261396.1  glutamic acid decarboxylase 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261396.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1G1, P20228, Q9VZI7
    UniProtKB/TrEMBL
    M9PH99
    Conserved Domains (1) summary
    pfam00282
    Location:64 → 434
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

  3. NM_079190.3 → NP_523914.2  glutamic acid decarboxylase 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523914.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1G1, P20228, Q9VZI7
    UniProtKB/TrEMBL
    M9PH99
    Related
    FBpp0073132
    Conserved Domains (1) summary
    pfam00282
    Location:64 → 434
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

  4. NM_168056.2 → NP_728931.1  glutamic acid decarboxylase 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728931.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1G1, P20228, Q9VZI7
    UniProtKB/TrEMBL
    M9PH99
    Related
    FBpp0073133
    Conserved Domains (1) summary
    pfam00282
    Location:64 → 434
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PH99 M9PH99
P20228.2 P20228

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