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Ack Activated Cdc42 kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38489, updated on 4-Jan-2025

Summary

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Official Symbol
Ackprovided by FlyBase
Official Full Name
Activated Cdc42 kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0028484
Locus tag
Dmel_CG14992
See related
AllianceGenome:FB:FBgn0028484
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ACK; ACK2; BcDNA:GH10777; CG14992; dACK; DAck; DACK; Dmel\CG14992; p145
Summary
Enables DNA-binding transcription factor binding activity; non-membrane spanning protein tyrosine kinase activity; and protein domain specific binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; embryonic development via the syncytial blastoderm; and negative regulation of hippo signaling. Acts upstream of with a positive effect on phospholipid metabolic process. Located in cell periphery; clathrin-coated vesicle; and cytoophidium. Part of protein-containing complex. Is expressed in adult head; embryonic leading edge cell; mitotic domain; and organism. Orthologous to human TNK2 (tyrosine kinase non receptor 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Ack in Genome Data Viewer
Location:
64A6-64A6; 3-10 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4108186..4114157)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4108186..4114157)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45670 Neighboring gene Fermitin 1 Neighboring gene Chd64 Neighboring gene ensconsin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ack kinase regulates CTP synthase filaments during Drosophila oogenesis. Strochlic TI, et al. EMBO Rep, 2014 Nov. PMID 25223282, Free PMC Article
  2. The sorting nexin, DSH3PX1, connects the axonal guidance receptor, Dscam, to the actin cytoskeleton. Worby CA, et al. J Biol Chem, 2001 Nov 9. PMID 11546816
  3. Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Schmucker D, et al. Cell, 2000 Jun 9. PMID 10892653
  4. ACK family tyrosine kinase activity is a component of Dcdc42 signaling during dorsal closure in Drosophila melanogaster. Sem KP, et al. Mol Cell Biol, 2002 Jun. PMID 11997505, Free PMC Article
  5. Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Clemens JC, et al. Proc Natl Acad Sci U S A, 2000 Jun 6. PMID 10823906, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Flies deficient in DAck catalytic activity have morphologically abnormal CTP synthase filaments, reduced RNA levels, membrane phospholipid defects and reduced fertility.
    Title: Ack kinase regulates CTP synthase filaments during Drosophila oogenesis.
  2. Results show that Src42a and Src64b are required for the normal division capacity of Drosophila intestinal progenitor cells, and that these genes as well as Ack cause progenitor overproliferation in the intestine via core cell cycle activation.
    Title: Src kinase function controls progenitor cell pools during regeneration and tumor onset in the Drosophila intestine.
  3. Data indicate that Activated Cdc42 kinase Ack forms a complex with dreadlocks via its SH2 domain.
    Title: Activated Cdc42 kinase regulates Dock localization in male germ cells during Drosophila spermatogenesis.
  4. We have shown that Ack function can suppress programmed cell death induced by hid or rpr expression in the developing eye and wing discs
    Title: Drosophila activated Cdc42 kinase has an anti-apoptotic function.
  5. ACK family tyrosine kinase activity is a component of Dcdc42 signaling during dorsal closure in Drosophila melanogaster.
    Title: ACK family tyrosine kinase activity is a component of Dcdc42 signaling during dorsal closure in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables SH2 domain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables SH3 domain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in CTP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to epidermal growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal closure, amnioserosa morphology change IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in head involution IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in myosin filament assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_positive_effect phospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in sperm individualization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoophidium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
activated Cdc42 kinase
Names
Ack-PA
CG14992-PA
NP_647859.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4108186..4114157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139602.3 → NP_647859.1  activated Cdc42 kinase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647859.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U4G3, Q9VZI2
    Related
    FBpp0073067
    Conserved Domains (3) summary
    cd09539
    Location:14 → 75
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    cd14328
    Location:1031 → 1070
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:128 → 385
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MRP0 Q8MRP0
Q9VZI2.2 Q9VZI2

Gene LinkOut

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