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Chd64 Chd64 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38490, updated on 9-Dec-2024

Summary

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Official Symbol
Chd64provided by FlyBase
Official Full Name
Chd64provided by FlyBase
Primary source
FLYBASE:FBgn0035499
Locus tag
Dmel_CG14996
See related
AllianceGenome:FB:FBgn0035499
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Liang-1.80; CG-14996; CG14996; clone 1.80; CT34849; Dmel\CG14996
Summary
Enables juvenile hormone response element binding activity. Involved in juvenile hormone mediated signaling pathway. Predicted to be located in striated muscle thin filament. Predicted to be active in actin cytoskeleton. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; epithelium; germline cell; and gut section. Orthologous to human TAGLN (transgelin); TAGLN2 (transgelin 2); and TAGLN3 (transgelin 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Chd64 in Genome Data Viewer
Location:
64A6-64A7; 3-10 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4114289..4122388, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4114289..4122388, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45670 Neighboring gene Activated Cdc42 kinase Neighboring gene ensconsin Neighboring gene Replication factor C subunit 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Insight into the Unfolding Properties of Chd64, a Small, Single Domain Protein with a Globular Core and Disordered Tails. Tarczewska A, et al. PLoS One, 2015. PMID 26325194, Free PMC Article
  2. Calponin-like Chd64 is partly disordered. Kozłowska M, et al. PLoS One, 2014. PMID 24805353, Free PMC Article
  3. Differential Expression of Drosophila Transgelins Throughout Development. Vakaloglou KM, et al. Front Cell Dev Biol, 2021. PMID 34322481, Free PMC Article
  4. Leading edge-secreted Dpp cooperates with ACK-dependent signaling from the amnioserosa to regulate myosin levels during dorsal closure. Zahedi B, et al. Dev Dyn, 2008 Oct. PMID 18816840
  5. Drosophila ensconsin promotes productive recruitment of Kinesin-1 to microtubules. Sung HH, et al. Dev Cell, 2008 Dec. PMID 19081075

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables juvenile hormone response element binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in juvenile hormone mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in smooth muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in striated muscle thin filament ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Chd64
Names
CG14996-PB
CG14996-PC
Chd64-PB
Chd64-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4114289..4122388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139603.3 → NP_647860.1  Chd64, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647860.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NHZ2, Q9VZI1
    Related
    FBpp0073126
    Conserved Domains (2) summary
    pfam00402
    Location:165 → 187
    Calponin; Calponin family repeat
    cl00030
    Location:22 → 131
    CH_SF; calponin homology (CH) domain superfamily

  2. NM_001274469.1 → NP_001261398.1  Chd64, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261398.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PE30
    Conserved Domains (2) summary
    pfam00402
    Location:152 → 174
    Calponin; Calponin family repeat
    cl00030
    Location:9 → 118
    CH_SF; calponin homology (CH) domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PE30 M9PE30
Q9VZI1 Q9VZI1

Gene LinkOut

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