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mas masquerade [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38499, updated on 9-Dec-2024

Summary

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Official Symbol
masprovided by FlyBase
Official Full Name
masqueradeprovided by FlyBase
Primary source
FLYBASE:FBgn0011653
Locus tag
Dmel_CG15002
See related
AllianceGenome:FB:FBgn0011653
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
c-SPH79; CG15002; cSPH79; Dmel\CG15002; Mas; SPH79
Summary
Involved in muscle attachment; nervous system development; and positive regulation of neuron projection development. Located in several cellular components, including axon; extracellular space; and neuronal cell body. Is expressed in several structures, including anlage in statu nascendi; dorsal ectoderm anlage; epithelium; gut section; and tracheal system. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See mas in Genome Data Viewer
Location:
64A8-64A8; 3-10 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4161666..4167464, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4161666..4167464, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene nab Neighboring gene long non-coding RNA:CR44529 Neighboring gene Endoplasmic reticulum oxidoreductin-1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Masquerade: a novel secreted serine protease-like molecule is required for somatic muscle attachment in the Drosophila embryo. Murugasu-Oei B, et al. Genes Dev, 1995 Jan 15. PMID 7851790
  2. Mutations in masquerade, a novel serine-protease-like molecule, affect axonal guidance and taste behavior in Drosophila. Murugasu-Oei B, et al. Mech Dev, 1996 Jun. PMID 8817456
  3. Separable cis-acting control elements for expression of the white gene of Drosophila. Levis R, et al. EMBO J, 1985 Dec 16. PMID 3004962, Free PMC Article
  4. Scarface, a secreted serine protease-like protein, regulates polarized localization of laminin A at the basement membrane of the Drosophila embryo. Sorrosal G, et al. EMBO Rep, 2010 May. PMID 20379222, Free PMC Article
  5. Drosophila hedgehog signaling and engrailed-runt mutual repression direct midline glia to alternative ensheathing and non-ensheathing fates. Watson JD, et al. Development, 2011 Apr. PMID 21350018, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
  
NOT enables serine-type endopeptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in central nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle attachment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection fasciculation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
masquerade
Names
CG15002-PB
CG15002-PC
mas-PB
mas-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4161666..4167464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274479.1 → NP_001261408.1  masquerade, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261408.1

    Status: REVIEWED

    Conserved Domains (2) summary
    smart00020
    Location:801 → 1037
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:802 → 1040
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_079195.3 → NP_523919.1  masquerade, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523919.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    M9PE44, Q24019, Q960I5, Q9VZH2
    Related
    FBpp0073116
    Conserved Domains (1) summary
    cd00190
    Location:803 → 1041
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZH2.1 Q9VZH2

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