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Teh2 tipE homolog 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38502, updated on 4-Jan-2025

Summary

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Official Symbol
Teh2provided by FlyBase
Official Full Name
tipE homolog 2provided by FlyBase
Primary source
FLYBASE:FBgn0035505
Locus tag
Dmel_CG15004
See related
AllianceGenome:FB:FBgn0035505
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15004; Dmel\CG15004; TEH1; TEH2
Summary
Enables sodium channel regulator activity. Involved in regulation of sodium ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Teh2 in Genome Data Viewer
Location:
64A9-64A10; 3-10 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4178980..4188023, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4178980..4188023, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Endoplasmic reticulum oxidoreductin-1-like Neighboring gene uncharacterized protein Neighboring gene tipE homolog 4 Neighboring gene Vacuolar H[+] ATPase M9.7 subunit c Neighboring gene tipE homolog 3 Neighboring gene temperature-induced paralytic E Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distinct modulating effects of TipE-homologs 2-4 on Drosophila sodium channel splice variants. Wang L, et al. Insect Biochem Mol Biol, 2015 May. PMID 25744892
  2. Alcohol-Induced Neuroadaptation Is Orchestrated by the Histone Acetyltransferase CBP. Ghezzi A, et al. Front Mol Neurosci, 2017. PMID 28442993, Free PMC Article
  3. A remarkably stable TipE gene cluster: evolution of insect Para sodium channel auxiliary subunits. Li J, et al. BMC Evol Biol, 2011 Nov 18. PMID 22098672, Free PMC Article
  4. Four novel sequences in Drosophila melanogaster homologous to the auxiliary Para sodium channel subunit TipE. Derst C, et al. Biochem Biophys Res Commun, 2006 Jan 20. PMID 16325765
  5. Alcohol-induced histone acetylation reveals a gene network involved in alcohol tolerance. Ghezzi A, et al. PLoS Genet, 2013. PMID 24348266, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. increased the amplitude of peak current, but did not alter the gating properties of three DmNav splice variants
    Title: Distinct modulating effects of TipE-homologs 2-4 on Drosophila sodium channel splice variants.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium channel regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of sodium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tipE homolog 2
Names
CG15004-PA
CG15004-PB
Teh2-PA
Teh2-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4178980..4188023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139610.4 → NP_647867.1  tipE homolog 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647867.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3DNE8, Q9VZG9
    Related
    FBpp0073114
    Conserved Domains (1) summary
    pfam16972
    Location:73 → 271
    TipE; Na+ channel auxiliary subunit TipE

  2. NM_001169874.3 → NP_001163345.1  tipE homolog 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163345.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3DNE8, B6IDT8
    Conserved Domains (1) summary
    pfam16972
    Location:73 → 271
    TipE; Na+ channel auxiliary subunit TipE
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B6IDT8 B6IDT8
Q9VZG9 Q9VZG9

Gene LinkOut

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