tipE temperature-induced paralytic E [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: tipEprovided by FlyBase
Official Full Name: temperature-induced paralytic Eprovided by FlyBase
Primary source: FLYBASE:FBgn0003710
Locus tag: Dmel_CG1232
See related: AllianceGenome:FB:FBgn0003710
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1232; Dmel\CG1232; tip-E; TipE
Summary: Enables sodium channel regulator activity. Involved in cellular response to heat; male courtship behavior, veined wing generated song production; and regulation of sodium ion transport. Located in plasma membrane. Is expressed in several structures, including Malpighian tubule primordium; amnioserosa anlage; endoderm anlage; organism subdivision; and sensory nervous system primordium. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (4188499..4193788)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (4188499..4193788)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

TipE is a sodium channel gating protein that causes a hyperpolarizing shift in the voltage-dependence of fast inactivation of DmNav26.
Title: Differential effects of TipE and a TipE-homologous protein on modulation of gating properties of sodium channels from Drosophila melanogaster.
tipE regulates Na+-dependent repetitive firing in Drosophila neurons.
Title: tipE regulates Na+-dependent repetitive firing in Drosophila neurons.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables sodium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated sodium channel activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in male courtship behavior, veined wing generated song production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transport	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

Names: CG1232-PA; CG1232-PB; temperature-induced paralysis locus E; temperature-induced paralysis, locus E; temperature-induced-paralytic-E; tipE-PA; tipE-PB

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