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ago archipelago [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38516, updated on 4-Jan-2025

Summary

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Official Symbol
agoprovided by FlyBase
Official Full Name
archipelagoprovided by FlyBase
Primary source
FLYBASE:FBgn0041171
Locus tag
Dmel_CG15010
See related
AllianceGenome:FB:FBgn0041171
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Ago; anon-WO0118547.345; cdc4; CG15010; Dmel\CG15010; DmFbw7; FBXW3; FBXW7; SCF[Ago]
Summary
Enables ubiquitin-specific protease binding activity. Involved in several processes, including DNA endoreduplication; negative regulation of imaginal disc growth; and respiratory system development. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in eye disc morphogenetic furrow; larval central nervous system; muscle cell of A1-7 ventral longitudinal muscle 1; and organism. Used to study developmental delay, hypotonia, and impaired language. Human ortholog(s) of this gene implicated in developmental delay, hypotonia, and impaired language. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See ago in Genome Data Viewer
Location:
64A11-64A12; 3-10 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4246343..4254306, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4246343..4254306, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45738 Neighboring gene Sulfide quinone oxidoreductase Neighboring gene pavarotti Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cell cycle. Archipelago of destruction. Schwab M, et al. Nature, 2001 Sep 20. PMID 11565017
  2. Myc degradation: dancing with ubiquitin ligases. Amati B. Proc Natl Acad Sci U S A, 2004 Jun 15. PMID 15187232, Free PMC Article
  3. Germline variants in tumor suppressor FBXW7 lead to impaired ubiquitination and a neurodevelopmental syndrome. Stephenson SEM, et al. Am J Hum Genet, 2022 Apr 7. PMID 35395208, Free PMC Article
  4. FUS-induced neurotoxicity is prevented by inhibiting GSK-3β in a Drosophila model of amyotrophic lateral sclerosis. Choi HJ, et al. Hum Mol Genet, 2022 Mar 21. PMID 34605896
  5. A Nucleolar Isoform of the Drosophila Ubiquitin Specific Protease dUSP36 Regulates MYC-Dependent Cell Growth. Thevenon D, et al. Front Cell Dev Biol, 2020. PMID 32637412, Free PMC Article

See all (123) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Findings indicate that Archipelago (Ago)/FBXW7 controls S6kinase (dS6K) protein levels, but do not impinge on the transcript level.
    Title: A Drosophila genetic screen for suppressors of S6kinase-dependent growth identifies the F-box subunit Archipelago/FBXW7.
  2. these findings identify Ago as a required element of a circuit that suppresses the tracheogenic activity of larval muscle cells by antagonizing the Sima-mediated transcriptional response to hypoxia.
    Title: The archipelago ubiquitin ligase subunit acts in target tissue to restrict tracheal terminal cell branching and hypoxic-induced gene expression.
  3. p53-mediated regulation of ectopic neural stem cells (NSC) self-renewal through the Ago/Cyc E axis becomes particularly important when NSC homeostasis is perturbed.
    Title: dp53 Restrains ectopic neural stem cell formation in the Drosophila brain in a non-apoptotic mechanism involving Archipelago and cyclin E.
  4. Notch-archipelago-cyclin E link represents a significant new cell cycle regulatory mechanism in the developing eye.
    Title: Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye.
  5. Ago loss induces hyperplasia of some organs but paradoxically reduces the size of the adult eye.
    Title: The archipelago tumor suppressor gene limits rb/e2f-regulated apoptosis in developing Drosophila tissues.
  6. novel function for the ago ubiquitin-ligase in tracheal morphogenesis via Trh and its target breathless, and suggest that ago has distinct functions in mitotic and post-mitotic cells that influence its role in development and disease
    Title: The Drosophila F-box protein Archipelago controls levels of the Trachealess transcription factor in the embryonic tracheal system.
  7. archipelago is an important inhibitor of Drosophila Myc in developing tissues, and can regulate Cyclin E levels and Notch activity.
    Title: The Drosophila F box protein archipelago regulates dMyc protein levels in vivo.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cyclin binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-specific protease binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA endoreduplication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in branch fusion, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of glial cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of imaginal disc growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of exit from mitosis TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of proteolysis TAS
Traceable Author Statement
more info
 PubMed 
involved_in trachea development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in trachea development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ventral cord development HMP PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
archipelago
Names
CG15010-PA
CG15010-PB
CG15010-PC
ago-PA
ago-PB
ago-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4246343..4254306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079198.3 → NP_523922.1  archipelago, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523922.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1G6, Q9VZF4
    Related
    FBpp0073101
    Conserved Domains (4) summary
    COG2319
    Location:981 → 1274
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:988 → 1264
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:892 → 938
    F-box-like; F-box-like
    sd00039
    Location:998 → 1033
    7WD40; WD40 repeat [structural motif]

  2. NM_168073.2 → NP_728965.1  archipelago, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728965.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1G6, Q9VZF4
    Related
    FBpp0073102
    Conserved Domains (4) summary
    COG2319
    Location:981 → 1274
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:988 → 1264
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:892 → 938
    F-box-like; F-box-like
    sd00039
    Location:998 → 1033
    7WD40; WD40 repeat [structural motif]

  3. NM_168072.2 → NP_728964.1  archipelago, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728964.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1G6, Q9VZF4
    Related
    FBpp0073103
    Conserved Domains (4) summary
    COG2319
    Location:981 → 1274
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:988 → 1264
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam12937
    Location:892 → 938
    F-box-like; F-box-like
    sd00039
    Location:998 → 1033
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZF4.1 Q9VZF4

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