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TP53INP Tumor protein p53 inducible nuclear protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38543, updated on 9-Dec-2024

Summary

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Official Symbol
TP53INPprovided by FlyBase
Official Full Name
Tumor protein p53 inducible nuclear proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0035542
Locus tag
Dmel_CG11347
See related
AllianceGenome:FB:FBgn0035542
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11347; dDOR; Dmel\CG11347; DOR
Summary
Enables nuclear receptor binding activity and nuclear receptor coactivator activity. Involved in several processes, including ecdysone receptor signaling pathway; positive regulation of ecdysone receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Predicted to be active in autophagosome and nucleus. Is expressed in several structures, including CNS glial cell; head epidermis primordium; sensory nervous system primordium; ventral nerve cord; and visceral mesoderm derivative. Orthologous to human TP53INP1 (tumor protein p53 inducible nuclear protein 1) and TP53INP2 (tumor protein p53 inducible nuclear protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See TP53INP in Genome Data Viewer
Location:
64B4-64B5; 3-12 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4406943..4420648)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4406943..4420648)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene slowdown Neighboring gene Syntaxin 17 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene nicotinic Acetylcholine Receptor beta1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TP53INP1 exerts neuroprotection under ageing and Parkinson's disease-related stress condition. Dinh E, et al. Cell Death Dis, 2021 May 8. PMID 33966044, Free PMC Article
  2. The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells. Mauvezin C, et al. EMBO Rep, 2010 Jan. PMID 20010805, Free PMC Article
  3. Concurrent targeting of GSK3 and MEK as a therapeutic strategy to treat pancreatic ductal adenocarcinoma. Fukuda J, et al. Cancer Sci, 2024 Apr. PMID 38320747, Free PMC Article
  4. A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing. Lu YX, et al. Elife, 2021 May 14. PMID 33988501, Free PMC Article
  5. dDOR is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling. Francis VA, et al. Curr Biol, 2010 Oct 26. PMID 20888228

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables nuclear receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear receptor coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ecdysone receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ecdysone receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
tumor protein p53 inducible nuclear protein
Names
CG11347-PA
CG11347-PB
CG11347-PC
CG11347-PD
CG11347-PE
CG11347-PF
CG11347-PG
CG11347-PH
TP53INP-PA
TP53INP-PB
TP53INP-PC
TP53INP-PD
TP53INP-PE
TP53INP-PF
TP53INP-PG
TP53INP-PH
diabetes and obesity regulated

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4406943..4420648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104033.2 → NP_001097503.1  tumor protein p53 inducible nuclear protein, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097503.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZC6, Q9VZC7
    Conserved Domains (1) summary
    pfam14839
    Location:111 → 376
    DOR; DOR family

  2. NM_168084.2 → NP_728991.1  tumor protein p53 inducible nuclear protein, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728991.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZC6, Q9VZC7
    Related
    FBpp0073150
    Conserved Domains (1) summary
    pfam14839
    Location:111 → 376
    DOR; DOR family

  3. NM_001259695.1 → NP_001246624.1  tumor protein p53 inducible nuclear protein, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246624.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NFM7
    Conserved Domains (1) summary
    pfam14839
    Location:111 → 406
    DOR; DOR family

  4. NM_168083.3 → NP_728990.1  tumor protein p53 inducible nuclear protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728990.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZC6, Q9VZC7
    Related
    FBpp0073151
    Conserved Domains (1) summary
    pfam14839
    Location:111 → 376
    DOR; DOR family

  5. NM_001259696.2 → NP_001246625.1  tumor protein p53 inducible nuclear protein, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246625.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NFM7
    Conserved Domains (1) summary
    pfam14839
    Location:111 → 406
    DOR; DOR family

  6. NM_139643.3 → NP_647900.1  tumor protein p53 inducible nuclear protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647900.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VZC6, Q9VZC7
    Related
    FBpp0073152
    Conserved Domains (1) summary
    pfam14839
    Location:111 → 376
    DOR; DOR family

  7. NM_168085.2 → NP_728992.1  tumor protein p53 inducible nuclear protein, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728992.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NN74, Q8IRB4
    Related
    FBpp0073153
    Conserved Domains (1) summary
    pfam14839
    Location:134 → 262
    DOR; DOR family

  8. NM_001104034.1 → NP_001097504.1  tumor protein p53 inducible nuclear protein, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097504.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JNK7, Q6NN74
    Conserved Domains (1) summary
    pfam14839
    Location:90 → 218
    DOR; DOR family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JNK7 A8JNK7
M9NFM7 M9NFM7
Q8IRB4 Q8IRB4
Q9VZC7 Q9VZC7

Gene LinkOut

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