LeuRS-m Leucyl-tRNA synthetase, mitochondrial [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: LeuRS-mprovided by FlyBase
Official Full Name: Leucyl-tRNA synthetase, mitochondrialprovided by FlyBase
Primary source: FLYBASE:FBgn0027085
Locus tag: Dmel_CG7479
See related: AllianceGenome:FB:FBgn0027085
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Aats-leu; CG7479; dLARS; Dmel\CG7479; LARS; LeuRS; LRS
Summary: Predicted to enable leucine-tRNA ligase activity. Predicted to be involved in leucyl-tRNA aminoacylation and mitochondrial translation. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; anal pad primordium; embryonic anal pad; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human LARS2 (leucyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (4825853..4829038)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (4825853..4829038)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA editing activity	IEA Inferred from Electronic Annotation more info
enables leucine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables leucine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables leucine-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables leucine-tRNA ligase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in leucyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in leucyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in leucyl-tRNA aminoacylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in leucyl-tRNA aminoacylation	TAS Traceable Author Statement more info	PubMed
involved_in mitochondrial translation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed

Names: CG7479-PA; LeuRS-m-PA; Leucyl-tRNA synthetase; mitochondrial leucyl-tRNA synthetase

NP_647932.1

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The following sections contain reference sequences that belong to a specific genome build. Explain