Klp64D Kinesin-like protein at 64D [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Klp64Dprovided by FlyBase
Official Full Name: Kinesin-like protein at 64Dprovided by FlyBase
Primary source: FLYBASE:FBgn0004380
Locus tag: Dmel_CG10642
See related: AllianceGenome:FB:FBgn0004380
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10642; Dmel\CG10642; DmKlp64D; KIF 3A; kif3A; Kif3A; KIF3A; Klp 64D; Klp4; KLP4; klp64D; KLP64D; KLP64Ddm
Summary: Enables microtubule motor activity. Involved in several processes, including non-motile cilium assembly; positive regulation of canonical Wnt signaling pathway; and transport along microtubule. Located in cilium and cytoplasm. Is expressed in head; larval central nervous system; larval ventral nerve cord; ovary; and sense organ. Orthologous to human KIF3A (kinesin family member 3A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (5356864..5359392, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (5349964..5352492, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Role of Armadillo repeat 2 and kinesin-II motor subunit Klp64D for wingless signaling in Drosophila.
Title: Role of Armadillo repeat 2 and kinesin-II motor subunit Klp64D for wingless signaling in Drosophila.
Klp64D is required for wing margin development. Reduced Klp64D function is suppressed by activated Arm.
Title: Kinesin-II recruits Armadillo and Dishevelled for Wingless signaling in Drosophila.
KLP64D and KLP68D Stalks Heterodimerize through the C-terminal 1/3rd Segments, and the Association is Stabilized by the N-terminal Segments.
Title: Biochemical and molecular dynamic simulation analysis of a weak coiled coil association between kinesin-II stalks.
KLP64D tail binds to endogenous ChAT
Title: Interaction with a kinesin-2 tail propels choline acetyltransferase flow towards synapse.
Data show that kinesin-2, and the +TIPS EB1 and APC, are required for uniform dendrite microtubule polarity.
Title: Directed microtubule growth, +TIPs, and kinesin-2 are required for uniform microtubule polarity in dendrites.
Klp64D function is essential for Bazooka (Par-3 homolog) and Armadillo localization to the adherens junction (AJ) in pupal photoreceptors.
Title: Kinesin II is required for cell survival and adherens junction positioning in Drosophila photoreceptors.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde axonal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in anterograde axonal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of microtubule cytoskeleton polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in sperm axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info

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