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Pfdn4 Prefoldin 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38615, updated on 9-Dec-2024

Summary

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Official Symbol
Pfdn4provided by FlyBase
Official Full Name
Prefoldin 4provided by FlyBase
Primary source
FLYBASE:FBgn0035603
Locus tag
Dmel_CG10635
See related
AllianceGenome:FB:FBgn0035603
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:SD11994; CG10635; Dmel\CG10635; pfdn4
Summary
Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Orthologous to human PFDN4 (prefoldin subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Pfdn4 in Genome Data Viewer
Location:
64C13-64C14; 3-13 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5367341..5368008, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5360441..5361108, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cytochrome c1 Neighboring gene Ubiquitin-conjugating enzyme variant 1A Neighboring gene membrin Neighboring gene long non-coding RNA:CR44515 Neighboring gene long non-coding RNA:CR44516

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Prefoldin and Pins synergistically regulate asymmetric division and suppress dedifferentiation. Zhang Y, et al. Sci Rep, 2016 Mar 30. PMID 27025979, Free PMC Article
  2. Misato Controls Mitotic Microtubule Generation by Stabilizing the TCP-1 Tubulin Chaperone Complex [corrected]. Palumbo V, et al. Curr Biol, 2015 Jun 29. PMID 26096973, Free PMC Article
  3. A genetic screen identifies new regulators of steroid-triggered programmed cell death in Drosophila. Wang L, et al. Genetics, 2008 Sep. PMID 18757938, Free PMC Article
  4. The genomic response to courtship song stimulation in female Drosophila melanogaster. Immonen E, et al. Proc Biol Sci, 2012 Apr 7. PMID 21976688, Free PMC Article
  5. Characterization of gene expression regulated by human OTK18 using Drosophila melanogaster as a model system for innate immunity. Spresser CR, et al. J Genet, 2008 Aug. PMID 18776638

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of prefoldin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of prefoldin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
prefoldin 4
Names
CG10635-PA
Pfdn4-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    5367341..5368008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139704.2 → NP_647961.1  prefoldin 4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647961.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VRL3
    UniProtKB/TrEMBL
    A0A1B2AKD0, Q8MRY9
    Related
    FBpp0076858
    Conserved Domains (1) summary
    pfam01920
    Location:26 → 129
    Prefoldin_2; Prefoldin subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MRY9 Q8MRY9
Q9VRL3.1 Q9VRL3

Gene LinkOut

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Chemical Information
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