Lkr Leucokinin receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Lkrprovided by FlyBase
Official Full Name: Leucokinin receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0035610
Locus tag: Dmel_CG10626
See related: AllianceGenome:FB:FBgn0035610
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0131005.17; anon-WO0170980.118; anon-WO0170980.119; CG10626; dLKR; DLKR; Dmel\CG10626; LK-R; lkr; LkR; LKR
Summary: Enables leucokinin receptor activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of feeding behavior; and positive regulation of cytosolic calcium ion concentration. Located in basolateral plasma membrane. Is expressed in several structures, including Malpighian tubule Type II cell; brain; gut section; neurosecretory cell of brain; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (5512421..5529341, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (5505521..5522441, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

encodes a functional leucokinin receptor
Title: Systematic G-protein-coupled receptor analysis in Drosophila melanogaster identifies a leucokinin receptor with novel roles.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables leucokinin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide Y receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide receptor activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISM Inferred from Sequence Model more info	PubMed
involved_in negative regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

Names: CG10626-PA; Lkr-PA; drosokinin receptor; kinin receptor; leucokinin R

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The following sections contain reference sequences that belong to a specific genome build. Explain