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Alp10 Alkaline phosphatase 10 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38632, updated on 4-Jan-2025

Summary

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Official Symbol
Alp10provided by FlyBase
Official Full Name
Alkaline phosphatase 10provided by FlyBase
Primary source
FLYBASE:FBgn0035619
Locus tag
Dmel_CG10592
See related
AllianceGenome:FB:FBgn0035619
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10592; Dmel\CG10592
Summary
Predicted to enable alkaline phosphatase activity. Predicted to be located in cell surface. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPG (alkaline phosphatase, germ cell); ALPI (alkaline phosphatase, intestinal); and ALPP (alkaline phosphatase, placental). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Alp10 in Genome Data Viewer
Location:
64D5-64D5; 3-14 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5592741..5595272, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5585841..5588372, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene small non-coding RNA 357 Neighboring gene Msr-110 Neighboring gene lethal (3) persistent salivary gland 2 Neighboring gene spook Neighboring gene Alkaline phosphatase 9 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic analyses of Drosophila melanogaster models of chromatin modification disorders. MacPherson RA, et al. Genetics, 2023 Aug 9. PMID 37036413, Free PMC Article
  2. Activation of innate immunity during development induces unresolved dysbiotic inflammatory gut and shortens lifespan. Yamashita K, et al. Dis Model Mech, 2021 Sep 1. PMID 34448472, Free PMC Article
  3. Two independent duplications forming the Cyp307a genes in Drosophila. Sztal T, et al. Insect Biochem Mol Biol, 2007 Oct. PMID 17785192
  4. Genomic response to selection for postponed senescence in Drosophila. Wilson RH, et al. Mech Ageing Dev, 2013 Mar. PMID 23262286, Free PMC Article
  5. An in vivo RNAi screen uncovers the role of AdoR signaling and adenosine deaminase in controlling intestinal stem cell activity. Xu C, et al. Proc Natl Acad Sci U S A, 2020 Jan 7. PMID 31852821, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alkaline phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alkaline phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
alkaline phosphatase 10
Names
Alp10-PA
CG10592-PA
NP_647976.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    5592741..5595272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139719.2 → NP_647976.1  alkaline phosphatase 10 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647976.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VRM8
    Related
    FBpp0076835, FBtr0077129
    Conserved Domains (2) summary
    COG1785
    Location:56 → 510
    PhoA; Alkaline phosphatase [Inorganic ion transport and metabolism, General function prediction only]
    cl23718
    Location:75 → 511
    ALP_like; alkaline phosphatases and sulfatases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VRM8 Q9VRM8

Gene LinkOut

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