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Bre1 Bre1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38652, updated on 4-Jan-2025

Summary

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Official Symbol
Bre1provided by FlyBase
Official Full Name
Bre1provided by FlyBase
Primary source
FLYBASE:FBgn0086694
Locus tag
Dmel_CG10542
See related
AllianceGenome:FB:FBgn0086694
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
bre-1; Bre-1; bre1; BRE1; CG10542; dBre1; dBRE1; Dmel\CG10542; EC3-8; l(3)01640
Summary
Enables ubiquitin protein ligase activity. Involved in chromatin organization; positive regulation of macromolecule biosynthetic process; and protein monoubiquitination. Located in nucleus. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to several human genes including RNF40 (ring finger protein 40). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Bre1 in Genome Data Viewer
Location:
64E8-64E8; 3-15 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5789831..5794192, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5782931..5787292, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45026 Neighboring gene Peptidoglycan recognition protein LD Neighboring gene Pmi Neighboring gene Cellular retinaldehyde binding protein Neighboring gene Tektin C Neighboring gene Ribosomal protein S6 kinase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. dBre1/dSet1-dependent pathway for histone H3K4 trimethylation has essential roles in controlling germline stem cell maintenance and germ cell differentiation in the Drosophila ovary. Xuan T, et al. Dev Biol, 2013 Jul 15. PMID 23624310
  2. A Toll-dependent Bre1/Rad6-cact feedback loop in controlling host innate immune response. Cai Q, et al. Cell Rep, 2022 Dec 13. PMID 36516751
  3. Computational identification of operon-like transcriptional loci in eukaryotes. Nannapaneni K, et al. Comput Biol Med, 2013 Jul. PMID 23668349
  4. Continuous tracking of startled Drosophila as an alternative to the negative geotaxis climbing assay. Taylor MJ, et al. J Neurogenet, 2019 Sep. PMID 31290369
  5. Eukaryotic operon-like transcription of functionally related genes in Drosophila. Ben-Shahar Y, et al. Proc Natl Acad Sci U S A, 2007 Jan 2. PMID 17190802, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. dBre1/dSet1-dependent pathway for histone H3K4 trimethylation has essential roles in controlling germline stem cell maintenance and germ cell differentiation in the Drosophila ovary.
    Title: dBre1/dSet1-dependent pathway for histone H3K4 trimethylation has essential roles in controlling germline stem cell maintenance and germ cell differentiation in the Drosophila ovary.
  2. identify Bre1 as a nuclear component required cell autonomously for the expression of Notch target genes in development
    Title: Bre1 is required for Notch signaling and histone modification.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein monoubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of HULC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Bre1
Names
Bre1-PA
Bre1-PB
CG10542-PA
CG10542-PB
lethal (3) 01640

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    5789831..5794192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300021.1 → NP_001286950.1  Bre1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286950.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C3KGI2, Q8IGT1, Q95TN7, Q9VRP9
    UniProtKB/TrEMBL
    X2JGB3
    Conserved Domains (3) summary
    TIGR02168
    Location:235 → 987
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam13476
    Location:654 → 762
    AAA_23; AAA domain
    pfam13923
    Location:991 → 1029
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

  2. NM_139732.3 → NP_647989.2  Bre1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647989.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C3KGI2, Q8IGT1, Q95TN7, Q9VRP9
    UniProtKB/TrEMBL
    X2JGB3
    Related
    FBpp0076822
    Conserved Domains (3) summary
    TIGR02168
    Location:235 → 987
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam13476
    Location:654 → 762
    AAA_23; AAA domain
    pfam13923
    Location:991 → 1029
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VRP9.2 Q9VRP9
X2JGB3 X2JGB3

Gene LinkOut

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