U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Bre1 Bre1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38652, updated on 9-Dec-2024

Summary

Official Symbol
Bre1provided by FlyBase
Official Full Name
Bre1provided by FlyBase
Primary source
FLYBASE:FBgn0086694
Locus tag
Dmel_CG10542
See related
AllianceGenome:FB:FBgn0086694
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
bre-1; Bre-1; bre1; BRE1; CG10542; dBre1; dBRE1; Dmel\CG10542; EC3-8; l(3)01640
Summary
Enables ubiquitin protein ligase activity. Involved in chromatin organization; positive regulation of macromolecule biosynthetic process; and protein monoubiquitination. Located in nucleus. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to several human genes including RNF40 (ring finger protein 40). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Bre1 in Genome Data Viewer
Location:
64E8-64E8; 3-15 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5789831..5794192, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5782931..5787292, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45026 Neighboring gene Peptidoglycan recognition protein LD Neighboring gene Pmi Neighboring gene Cellular retinaldehyde binding protein Neighboring gene Tektin C Neighboring gene Ribosomal protein S6 kinase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding ISM
Inferred from Sequence Model
more info
PubMed 
Component Evidence Code Pubs
part_of HULC complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Bre1
Names
Bre1-PA
Bre1-PB
CG10542-PA
CG10542-PB
lethal (3) 01640

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    5789831..5794192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300021.1NP_001286950.1  Bre1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286950.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C3KGI2, Q8IGT1, Q95TN7, Q9VRP9
    UniProtKB/TrEMBL
    X2JGB3
    Conserved Domains (3) summary
    TIGR02168
    Location:235987
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam13476
    Location:654762
    AAA_23; AAA domain
    pfam13923
    Location:9911029
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
  2. NM_139732.3NP_647989.2  Bre1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647989.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C3KGI2, Q8IGT1, Q95TN7, Q9VRP9
    UniProtKB/TrEMBL
    X2JGB3
    Related
    FBpp0076822
    Conserved Domains (3) summary
    TIGR02168
    Location:235987
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam13476
    Location:654762
    AAA_23; AAA domain
    pfam13923
    Location:9911029
    zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)