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KRTAP10-9 keratin associated protein 10-9 [ Homo sapiens (human) ]

Gene ID: 386676, updated on 10-Dec-2024

Summary

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Official Symbol
KRTAP10-9provided by HGNC
Official Full Name
keratin associated protein 10-9provided by HGNC
Primary source
HGNC:HGNC:22971
See related
Ensembl:ENSG00000221837 AllianceGenome:HGNC:22971
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAP10.9; KAP18.9; KRTAP18-9
Orthologs
all
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Genomic context

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See KRTAP10-9 in Genome Data Viewer
Location:
21q22.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (44627093..44628378)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (42987533..42988824)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (46047010..46048295)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene thrombospondin type laminin G domain and EAR repeats Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46020385-46021145 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46021146-46021905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46022006-46022862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46022863-46023717 Neighboring gene keratin associated protein 10-7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46031985-46032634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46032635-46033283 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46036915-46037661 Neighboring gene keratin associated protein 10-8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46045935-46046630 Neighboring gene keratin associated protein 10-10 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46067006-46067870 Neighboring gene keratin associated protein 10-11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21. Rogers MA, et al. J Invest Dermatol, 2004 Jan. PMID 14962103
  2. A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3. Shibuya K, et al. Genomics, 2004 Apr. PMID 15028290
  3. Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor. Daakour S, et al. BMC Cancer, 2016 May 26. PMID 27229929, Free PMC Article
  4. The DNA sequence of human chromosome 21. Hattori M, et al. Nature, 2000 May 18. PMID 10830953
  5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao Z, et al. Mol Cell, 2017 Jan 19. PMID 28065597, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
keratin-associated protein 10-9
Names
high sulfur keratin-associated protein 10.9
keratin associated protein 18-9
keratin-associated protein 10.9
keratin-associated protein 18.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198690.3 → NP_941963.2  keratin-associated protein 10-9

    See identical proteins and their annotated locations for NP_941963.2

    Status: VALIDATED

    Source sequence(s)
    AB076356, AJ566386, AL773602
    Consensus CDS
    CCDS42961.1
    UniProtKB/Swiss-Prot
    A2RRG1, A6NIR9, P60411, Q70LJ1
    Related
    ENSP00000381009.3, ENST00000397911.5
    Conserved Domains (2) summary
    pfam01500
    Location:34 → 197
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam13885
    Location:109 → 154
    Keratin_B2_2; Keratin, high sulfur B2 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    44627093..44628378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    42987533..42988824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60411.2 GenPept UniProtKB/Swiss-Prot:P60411

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
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