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dnajb11 DnaJ heat shock protein family (Hsp40) member B11 [ Danio rerio (zebrafish) ]

Gene ID: 386709, updated on 4-Jan-2025

Summary

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Official Symbol
dnajb11provided by ZNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member B11provided by ZNC
Primary source
ZFIN:ZDB-GENE-031113-9
See related
Ensembl:ENSDARG00000015088 AllianceGenome:ZFIN:ZDB-GENE-031113-9
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb954
Summary
Predicted to enable misfolded protein binding activity and unfolded protein binding activity. Predicted to be involved in protein maturation. Predicted to act upstream of or within protein folding. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including axial mesoderm; blood vessel; nervous system; neural tube; and pectoral fin. Human ortholog(s) of this gene implicated in polycystic kidney disease 6. Orthologous to human DNAJB11 (DnaJ heat shock protein family (Hsp40) member B11). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See dnajb11 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (32641028..32648692, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (32830282..32837952, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene phospholipase C like 1 Neighboring gene SATB homeobox 2 Neighboring gene RAB, member of RAS oncogene family-like 3 Neighboring gene granzyme 3, tandem duplicate 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mother-Specific Signature in the Maternal Transcriptome Composition of Mature, Unfertilized Zebrafish Eggs. Rauwerda H, et al. PLoS One, 2016. PMID 26799215, Free PMC Article
  2. Eye-specific gene expression following embryonic ethanol exposure in zebrafish: roles for heat shock factor 1. Kashyap B, et al. Reprod Toxicol, 2014 Jan. PMID 24355176, Free PMC Article
  3. RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish. Yang D, et al. BMC Genomics, 2012 Jul 17. PMID 22805612, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily B member 11
Names
DnaJ (Hsp40) homolog, subfamily B, member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198821.1 → NP_942116.1  dnaJ homolog subfamily B member 11 precursor

    See identical proteins and their annotated locations for NP_942116.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044559
    UniProtKB/TrEMBL
    Q803A9
    Conserved Domains (3) summary
    cd10747
    Location:134 → 331
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:24 → 346
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:27 → 89
    DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    32641028..32648692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167678.5 → XP_005167735.1  dnaJ homolog subfamily B member 11 isoform X1

    See identical proteins and their annotated locations for XP_005167735.1

    UniProtKB/TrEMBL
    A9JRS7, Q6NYZ0
    Related
    ENSDARP00000107433.2, ENSDART00000123374.4
    Conserved Domains (3) summary
    cd10747
    Location:134 → 331
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:24 → 346
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:27 → 89
    DnaJ; DnaJ domain

  2. XM_021478626.2 → XP_021334301.1  dnaJ homolog subfamily B member 11 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QFA3
    Conserved Domains (1) summary
    COG0484
    Location:1 → 324
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein Strain
Heading Accession and Version

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