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alphaKap4 alpha Karyopherin-4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38675, updated on 9-Dec-2024

Summary

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Official Symbol
alphaKap4provided by FlyBase
Official Full Name
alpha Karyopherin-4provided by FlyBase
Primary source
FLYBASE:FBgn0035657
Locus tag
Dmel_CG10478
See related
AllianceGenome:FB:FBgn0035657
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10478; CG11040; Dmel\CG10478; g7295403
Summary
Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Is expressed in testis. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See alphaKap4 in Genome Data Viewer
Location:
65A2-65A2; 3-16 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6009446..6011021, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6002546..6004121, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45439 Neighboring gene long non-coding RNA:CR45440 Neighboring gene PVR adaptor protein Neighboring gene uncharacterized protein Neighboring gene yippee interacting protein 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolution of the metazoan-specific importin alpha gene family. Mason DA, et al. J Mol Evol, 2009 Apr. PMID 19308634
  2. Drosophila melanogaster importin alpha1 and alpha3 can replace importin alpha2 during spermatogenesis but not oogenesis. Mason DA, et al. Genetics, 2002 May. PMID 12019231, Free PMC Article
  3. Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus. Jang AR, et al. PLoS Genet, 2015 Feb. PMID 25674790, Free PMC Article
  4. Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects. Mirsalehi A, et al. BMC Genomics, 2021 Dec 5. PMID 34863092, Free PMC Article
  5. Birth, death, and replacement of karyopherins in Drosophila. Phadnis N, et al. Mol Biol Evol, 2012 May. PMID 22160828, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear import signal receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
alpha Karyopherin-4
Names
CG10478-PA
alphaKap4-PA
importin alpha4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    6009446..6011021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139750.2 → NP_648007.1  alpha Karyopherin-4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648007.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G9LQY8, G9LQZ0, G9LQZ1, Q9VRS0
    Related
    FBpp0076777
    Conserved Domains (3) summary
    cd00020
    Location:189 → 301
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam16186
    Location:400 → 433
    Arm_3; Atypical Arm repeat
    sd00043
    Location:192 → 217
    ARM; armadillo repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VRS0 Q9VRS0

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