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bicra BRD4 interacting chromatin remodeling complex associated protein [ Danio rerio (zebrafish) ]

Gene ID: 386775, updated on 4-Jan-2025

Summary

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Official Symbol
bicraprovided by ZNC
Official Full Name
BRD4 interacting chromatin remodeling complex associated proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-031116-2
See related
Ensembl:ENSDARG00000061159 AllianceGenome:ZFIN:ZDB-GENE-031116-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
gltscr1; sb:cb888; wu:fc28g11; si:dkey-224e22.6
Summary
Acts upstream of or within embryonic cranial skeleton morphogenesis. Is expressed in several structures, including hindbrain neural plate; intermediate cell mass of mesoderm; midbrain neural keel; nervous system; and presumptive telencephalon. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 12. Orthologous to human BICRA (BRD4 interacting chromatin remodeling complex associated protein). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See bicra in Genome Data Viewer
Location:
chromosome: 18
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (44628844..44646968)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (44634296..44653514)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene sprouty related EVH1 domain containing 3 Neighboring gene proteasome 26S subunit, non-ATPase 8 Neighboring gene EH-domain containing 2b Neighboring gene uncharacterized LOC137488335

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms. Barish S, et al. Am J Hum Genet, 2020 Dec 3. PMID 33232675, Free PMC Article
  2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms.
    Title: BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
glioma tumor suppressor candidate region gene 1 protein; BRD4-interacting chromatin-remodeling complex-associated protein
Names
glioma tumor suppressor candidate region gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    44628844..44646968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159252.5 → XP_005159309.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X1

    UniProtKB/TrEMBL
    A0A8M2B5V9
    Conserved Domains (1) summary
    pfam15249
    Location:1156 → 1260
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  2. XM_005159253.5 → XP_005159310.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X2

    UniProtKB/TrEMBL
    A0A8M2B5S5
    Conserved Domains (1) summary
    pfam15249
    Location:1156 → 1259
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  3. XM_005159254.5 → XP_005159311.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X5

    UniProtKB/TrEMBL
    A0A8M2B5S4
    Conserved Domains (1) summary
    pfam15249
    Location:1094 → 1198
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  4. XM_068214939.1 → XP_068071040.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X6

  5. XM_001922789.8 → XP_001922824.3  BRD4-interacting chromatin-remodeling complex-associated protein isoform X3

    UniProtKB/TrEMBL
    A0A8M1QHS7
    Conserved Domains (1) summary
    pfam15249
    Location:1134 → 1238
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  6. XM_068214938.1 → XP_068071039.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X4

    Related
    ENSDARP00000122886.1, ENSDART00000144271.2

  7. XM_068214940.1 → XP_068071041.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X7

    Related
    ENSDARP00000089311.4, ENSDART00000098540.4
Nucleotide Protein
Heading Accession and Version

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