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Jon65Aiii Jonah 65Aiii [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38683, updated on 4-Jan-2025

Summary

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Official Symbol
Jon65Aiiiprovided by FlyBase
Official Full Name
Jonah 65Aiiiprovided by FlyBase
Primary source
FLYBASE:FBgn0035665
Locus tag
Dmel_CG6483
See related
AllianceGenome:FB:FBgn0035665
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:GressD16; anon-WO0140519.59; CG6483; Dmel\CG6483; Jon65; Jon65A; jon65Aiii; SP98
Summary
Enables serine hydrolase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. Is expressed in embryonic midgut chamber; embryonic/larval midgut; and organism. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Jon65Aiii in Genome Data Viewer
Location:
65A3-65A3; 3-16 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6050757..6051690)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6043857..6044790)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Jonah 65Aiv Neighboring gene Jonah 65Aii Neighboring gene Jonah 65Ai

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hybridization fingerprinting of high-density cDNA-library arrays with cDNA pools derived from whole tissues. Gress TM, et al. Mamm Genome, 1992. PMID 1450511
  2. Homeostasis of glutamate neurotransmission is altered in Drosophila Inositol 1,4,5-trisphosphate receptor mutants. Nair S, et al. Invert Neurosci, 2007 Sep. PMID 17492321
  3. Developmental and functional analysis of Jonah gene expression. Carlson JR, et al. Dev Biol, 1985 Apr. PMID 2416611
  4. Genome-wide patterns of adaptation to temperate environments associated with transposable elements in Drosophila. González J, et al. PLoS Genet, 2010 Apr 8. PMID 20386746, Free PMC Article
  5. A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes. Bozler J, et al. PLoS Genet, 2017 Oct. PMID 29084214, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
enables serine hydrolase activity HDA PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
jonah 65Aiii
Names
CG6483-PA
Jon65Aiii-PA
jonah 65
jonah 65A
NP_648013.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    6050757..6051690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139756.3 → NP_648013.1  jonah 65Aiii [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648013.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VRS7
    Related
    FBpp0076749
    Conserved Domains (2) summary
    smart00020
    Location:39 → 266
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:40 → 269
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VRS7 Q9VRS7

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