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ndl nudel [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38738, updated on 4-Jan-2025

Summary

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Official Symbol
ndlprovided by FlyBase
Official Full Name
nudelprovided by FlyBase
Primary source
FLYBASE:FBgn0002926
Locus tag
Dmel_CG10129
See related
AllianceGenome:FB:FBgn0002926
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10129; Dmel\CG10129; mat(3)2; mel(3)5; Ndl; nud; SP89
Summary
Enables serine-type endopeptidase activity. Involved in several processes, including egg activation; egg chorion assembly; and protein maturation. Located in perivitelline space. Is expressed in follicle cell and ovary. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See ndl in Genome Data Viewer
Location:
65B5-65B5; 3-17 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6593938..6603366, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6587038..6596466, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene sulfateless Neighboring gene long non-coding RNA:CR46500 Neighboring gene Mitochondrial calcium uniporter Neighboring gene javelin Neighboring gene long non-coding RNA:CR45418 Neighboring gene RNA exonuclease 5 Neighboring gene zero population growth

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The maternal nudel protein of Drosophila has two distinct roles important for embryogenesis. Hong CC, et al. Genetics, 1996 Aug. PMID 8844153, Free PMC Article
  2. Biochemical defects of mutant nudel alleles causing early developmental arrest or dorsalization of the Drosophila embryo. LeMosy EK, et al. Genetics, 2000 Jan. PMID 10628985, Free PMC Article
  3. Evidence for a glycosaminoglycan on the nudel protein important for dorsoventral patterning of the drosophila embryo. Turcotte CL, et al. Dev Dyn, 2002 May. PMID 11984873
  4. Three-dimensional models of proteases involved in patterning of the Drosophila Embryo. Crucial role of predicted cation binding sites. Rose T, et al. J Biol Chem, 2003 Mar 28. PMID 12493753
  5. Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos. Steen PW, et al. FEBS Lett, 2010 Aug 20. PMID 20638387, Free PMC Article

See all (119) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. proteolytically processed segments of Nudel are secreted into the perivitelline space; however, there is no requirement for nudel to be expressed in ventral, pipe-expressing follicle cells
    Title: No requirement for localized Nudel protein expression in Drosophila embryonic axis determination.
  2. Data show that the N-terminal region of Nudel contains a site for glycosaminoglycan (GAG) attachment that is required for dorsoventral patterning.
    Title: Evidence for a glycosaminoglycan on the nudel protein important for dorsoventral patterning of the drosophila embryo.
  3. provision of three-dimensional model and role of cation binding sites in embryo patterning
    Title: Three-dimensional models of proteases involved in patterning of the Drosophila Embryo. Crucial role of predicted cation binding sites.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in Toll receptor ligand protein activation cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Toll receptor ligand protein activation cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal/ventral axis specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dorsal/ventral axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in egg activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in egg chorion assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autoprocessing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in zymogen activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perivitelline space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nudel
Names
CG10129-PA
ndl-PA
NP_523947.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    6593938..6603366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079223.2 → NP_523947.2  nudel [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523947.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P98159, Q9VRX5
    Related
    FBpp0076693, FBtr0076984
    Conserved Domains (6) summary
    pfam09595
    Location:1448 → 1600
    Metaviral_G; Metaviral_G glycoprotein
    smart00192
    Location:2350 → 2383
    LDLa; Low-density lipoprotein receptor domain class A
    smart00020
    Location:1144 → 1377
    Tryp_SPc; Trypsin-like serine protease
    cd00112
    Location:2421 → 2457
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:1145 → 1379
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09342
    Location:2041 → 2158
    DUF1986; Domain of unknown function (DUF1986)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P98159.2 P98159

Gene LinkOut

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