U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

axed axundead [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38741, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
axedprovided by FlyBase
Official Full Name
axundeadprovided by FlyBase
Primary source
FLYBASE:FBgn0035708
Locus tag
Dmel_CG8398
See related
AllianceGenome:FB:FBgn0035708
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey31; Axed; CG8398; Dmel\CG8398
Summary
Predicted to be involved in neurogenesis. Predicted to be active in cytosol. Is expressed in adult brain; adult head; larval ventral nerve cord; and yolk nucleus. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See axed in Genome Data Viewer
Location:
65C1-65C1; 3-17 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6609325..6619113)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6602425..6612213)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene RNA exonuclease 5 Neighboring gene long non-coding RNA:CR45418 Neighboring gene zero population growth Neighboring gene Glutamate receptor IA Neighboring gene long non-coding RNA:CR45238

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Programmed axon degeneration: from mouse to mechanism to medicine. Coleman MP, et al. Nat Rev Neurosci, 2020 Apr. PMID 32152523, Free PMC Article
  2. Axon death signalling in Wallerian degeneration among species and in disease. Llobet Rosell A, et al. Open Biol, 2019 Aug 30. PMID 31455157, Free PMC Article
  3. Transcription factor Pebbled/RREB1 regulates injury-induced axon degeneration. Farley JE, et al. Proc Natl Acad Sci U S A, 2018 Feb 6. PMID 29295933, Free PMC Article
  4. The NAD(+) precursor NMN activates dSarm to trigger axon degeneration in Drosophila. Llobet Rosell A, et al. Elife, 2022 Dec 23. PMID 36476387, Free PMC Article
  5. The Drosophila javelin gene encodes a novel actin-associated protein required for actin assembly in the bristle. Shapira S, et al. Mol Cell Biol, 2011 Nov. PMID 21930794, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
axundead
Names
CG8398-PA
CG8398-PC
CG8398-PD
CG8398-PE
CG8398-PF
axed-PA
axed-PC
axed-PD
axed-PE
axed-PF

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    6609325..6619113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001370050.1 → NP_001356975.1  axundead, isoform F [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4D6K4X9, C9QPJ5
    Conserved Domains (2) summary
    smart00225
    Location:192 → 258
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cl28903
    Location:354 → 423
    BACK; BACK (BTB and C-terminal Kelch) domain

  2. NM_139794.3 → NP_648051.1  axundead, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648051.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C9QPJ5, Q9VRX8
    Related
    FBpp0076687
    Conserved Domains (2) summary
    smart00225
    Location:192 → 258
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:348 → 442
    BACK; BTB And C-terminal Kelch

  3. NM_206283.2 → NP_996005.1  axundead, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996005.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V1K1, Q6AWD2, Q8T8V7
    Conserved Domains (2) summary
    smart00225
    Location:90 → 156
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:246 → 340
    BACK; BTB And C-terminal Kelch

  4. NM_168174.3 → NP_729180.1  axundead, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729180.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V1K1, Q6AWD2, Q8T8V7
    Related
    FBpp0076689
    Conserved Domains (2) summary
    smart00225
    Location:90 → 156
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:246 → 340
    BACK; BTB And C-terminal Kelch

  5. NM_168173.2 → NP_729179.1  axundead, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729179.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V1K1, Q6AWD2, Q8T8V7
    Related
    FBpp0303217
    Conserved Domains (2) summary
    smart00225
    Location:90 → 156
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:246 → 340
    BACK; BTB And C-terminal Kelch
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A4D6K4X9 A0A4D6K4X9
A4V1K1 A4V1K1
Q9VRX8 Q9VRX8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools