Prat2 Phosphoribosylamidotransferase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Prat2provided by FlyBase
Official Full Name: Phosphoribosylamidotransferase 2provided by FlyBase
Primary source: FLYBASE:FBgn0041194
Locus tag: Dmel_CG10078
See related: AllianceGenome:FB:FBgn0041194
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10078; Dmel\CG10078; DmPrat2
Summary: Predicted to enable amidophosphoribosyltransferase activity. Predicted to be involved in purine nucleotide biosynthetic process. Is expressed in adult head; adult heart; organism; and yolk nucleus. Orthologous to human PPAT (phosphoribosyl pyrophosphate amidotransferase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 65D2-65D3; 3-18 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (6911999..6914876, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (6905099..6907976, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prat2 is required during the prepupal stage while Prat is more important for the pupal stage; Prat2 is essential for fly development.
Title: The purine synthesis gene Prat2 is required for Drosophila metamorphosis, as revealed by inverted-repeat-mediated RNA interference.
Evidence suggests that Prat originated by gene duplication by retrotransposition of Prat2.
Title: The PRAT purine synthesis gene duplication in Drosophila melanogaster and Drosophila virilis is associated with a retrotransposition event and diversification of expression patterns.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables amidophosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables amidophosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in purine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphoribosylamidotransferase 2

Names: CG10078-PA; CG10078-PB; Phosphoribosylamidotransferase-2; Prat2-PA; Prat2-PB; amidophosphoribosyltransferase; phosphoribosyl amidotransferase 2

NP_523949.2

EC 2.4.2.14

NP_729191.1

EC 2.4.2.14

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

6911999..6914876 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079225.3 → NP_523949.2 phosphoribosylamidotransferase 2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523949.2

Status: REVIEWED

UniProtKB/TrEMBL

Q967S0

Related

FBpp0076654

Conserved Domains (3) summary

cd06223
Location:351 → 487

PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

COG0034
Location:57 → 544

PurF; Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]

cd00715
Location:58 → 340

GPATase_N; Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the ...
NM_168181.2 → NP_729191.1 phosphoribosylamidotransferase 2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729191.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VRZ1

Related

FBpp0076655

Conserved Domains (3) summary

cd06223
Location:274 → 410

PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

COG0034
Location:2 → 467

PurF; Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]

cd00715
Location:2 → 263

GPATase_N; Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the ...