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Acbp2 Acyl-CoA binding protein 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38784, updated on 4-Jan-2025

Summary

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Official Symbol
Acbp2provided by FlyBase
Official Full Name
Acyl-CoA binding protein 2provided by FlyBase
Primary source
FLYBASE:FBgn0010387
Locus tag
Dmel_CG8627
See related
AllianceGenome:FB:FBgn0010387
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ACBP; anon-WO0172774.131; BcDNA:RH39533; CG8627; dbi; Dbi; DBI; DmDBI; Dmel\CG8627
Summary
Predicted to enable fatty-acyl-CoA binding activity. Predicted to be involved in fatty acid metabolic process and intracellular acyl-CoA homeostasis. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic/larval fat body; and gut section. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human DBI (diazepam binding inhibitor, acyl-CoA binding protein). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Acbp2 in Genome Data Viewer
Location:
65E4-65E4; 3-19 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7131863..7133463)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7124963..7126563)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Acyl-CoA binding protein 6 Neighboring gene Acyl-CoA binding protein 3 Neighboring gene melted Neighboring gene cornetto Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tissue-specific expression of the diazepam-binding inhibitor in Drosophila melanogaster: cloning, structure, and localization of the gene. Kolmer M, et al. Mol Cell Biol, 1994 Oct. PMID 7935415, Free PMC Article
  2. Natural variation of gene models in Drosophila melanogaster. Kurmangaliyev YZ, et al. BMC Genomics, 2015 Mar 17. PMID 25888292, Free PMC Article
  3. Metabolomics provide new insights into mechanisms of Wolbachia-induced paternal defects in Drosophila melanogaster. Zhang HB, et al. PLoS Pathog, 2021 Aug. PMID 34383852, Free PMC Article
  4. New insights into the functions of ACBD4/5-like proteins using a combined phylogenetic and experimental approach across model organisms. Kors S, et al. Biochim Biophys Acta Mol Cell Res, 2024 Dec. PMID 39271061
  5. The ACBP gene family in Rhodnius prolixus: Expression, characterization and function of RpACBP-1. Majerowicz D, et al. Insect Biochem Mol Biol, 2016 May. PMID 27001070

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables fatty-acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty-acyl-CoA binding IEA
Inferred from Electronic Annotation
more info
  
enables fatty-acyl-CoA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular acyl-CoA homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Acyl-CoA binding protein 2
Names
Acbp2-PA
Acbp2-PB
CG8627-PA
CG8627-PB
Diazepam-binding inhibitor
acyl-CoA binding protein
acyl-CoA-binding protein
diazepam binding inhibitor
diazepam-binding protein
endozepine

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    7131863..7133463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168192.3 → NP_729218.1  Acyl-CoA binding protein 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729218.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1K8, P42281, Q9VS23
    UniProtKB/TrEMBL
    A0A1B2AIW6
    Related
    FBpp0076624
    Conserved Domains (1) summary
    cd00435
    Location:2 → 86
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

  2. NM_079228.3 → NP_523952.2  Acyl-CoA binding protein 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523952.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1K8, P42281, Q9VS23
    UniProtKB/TrEMBL
    A0A1B2AIW6
    Related
    FBpp0076625
    Conserved Domains (1) summary
    cd00435
    Location:2 → 86
    ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42281.1 P42281

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