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Dscam2 Down syndrome cell adhesion molecule 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38788, updated on 9-Dec-2024

Summary

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Official Symbol
Dscam2provided by FlyBase
Official Full Name
Down syndrome cell adhesion molecule 2provided by FlyBase
Primary source
FLYBASE:FBgn0265296
Locus tag
Dmel_CG42256
See related
AllianceGenome:FB:FBgn0265296
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:AT03867; CG14828; CG17742; CG32387; CG32389; CG42256; CG8618; CG8619; CT14580; CT14584; CT34644; Dmel\CG42256; DSCAM; Dscam-like
Old locus tag
Dmel_CG32387; Dmel_CG32389
Summary
Enables identical protein binding activity. Involved in homophilic cell adhesion via plasma membrane adhesion molecules and neuron projection morphogenesis. Predicted to be active in axon and plasma membrane. Is expressed in adult head; eye disc; and spermatozoon. Orthologous to human DSCAM (DS cell adhesion molecule) and DSCAML1 (DS cell adhesion molecule like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Dscam2 in Genome Data Viewer
Location:
65E6-65E7; 3-19 cM
Exon count:
24
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7159199..7189931, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7152299..7183031, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene melted Neighboring gene cornetto Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45410 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dscam2 affects visual perception in Drosophila melanogaster. Bosch DS, et al. Front Behav Neurosci, 2015. PMID 26106310, Free PMC Article
  2. Cell-specific alternative splicing of Drosophila Dscam2 is crucial for proper neuronal wiring. Lah GJ, et al. Neuron, 2014 Sep 17. PMID 25175881
  3. Drosophila dscam proteins regulate postsynaptic specificity at multiple-contact synapses. Millard SS, et al. Neuron, 2010 Sep 9. PMID 20826308, Free PMC Article
  4. Drosophila larval motor patterning relies on regulated alternative splicing of Dscam2. Odierna GL, et al. Front Mol Neurosci, 2024. PMID 39092203, Free PMC Article
  5. Regulated Alternative Splicing of Drosophila Dscam2 Is Necessary for Attaining the Appropriate Number of Photoreceptor Synapses. Kerwin SK, et al. Genetics, 2018 Feb. PMID 29208630, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dscam2 suppresses synaptic strength through a PI3K-dependent endosomal pathway.
    Title: Dscam2 suppresses synaptic strength through a PI3K-dependent endosomal pathway.
  2. Mbl protein controls Dscam2 alternative splicing. Mbl represses Dscam2 isoform A and promotes the selection of isoform B.
    Title: Deterministic splicing of Dscam2 is regulated by Muscleblind.
  3. different combinations of Dscam proteins act through distinct mechanisms in closely related neurons to pattern neural circuits.
    Title: Dscam Proteins Direct Dendritic Targeting through Adhesion.
  4. cell-specific expression of two biochemically distinct alternative isoforms of Dscam2 prevents, L1 and L2 neurons from repelling each other
    Title: Cell-specific alternative splicing of Drosophila Dscam2 is crucial for proper neuronal wiring.
  5. the immunoglobulin superfamily member Dscam2 restricts the connections formed by L1 lamina neurons to columns in the Drosophila visual system
    Title: Dscam2 mediates axonal tiling in the Drosophila visual system.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendrite self-avoidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
down syndrome cell adhesion molecule 2
Names
CG42256-PE
CG42256-PF
CG42256-PG
CG42256-PH
CG42256-PI
CG42256-PJ
CG42256-PK
CG42256-PL
CG42256-PM
CG42256-PN
CG42256-PO
CG42256-PP
CG42256-PQ
CG42256-PR
CG42256-PS
Dscam2-PE
Dscam2-PF
Dscam2-PG
Dscam2-PH
Dscam2-PI
Dscam2-PJ
Dscam2-PK
Dscam2-PL
Dscam2-PM
Dscam2-PN
Dscam2-PO
Dscam2-PP
Dscam2-PQ
Dscam2-PR
Dscam2-PS

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    7159199..7189931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168196.4 → NP_729225.2  down syndrome cell adhesion molecule 2, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729225.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7Z0C6, B7Z0C7, B7Z0C8, Q0E8H6, Q8MTB2, Q9VS28, Q9VS29, Q9VS30
    Conserved Domains (6) summary
    cd00096
    Location:822 → 893
    Ig; Immunoglobulin domain
    smart00408
    Location:533 → 597
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:432 → 517
    IG_like; Immunoglobulin like
    cd00063
    Location:905 → 1000
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:521 → 610
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:724 → 801
    Ig; Immunoglobulin domain

  2. NM_001300035.1 → NP_001286964.1  down syndrome cell adhesion molecule 2, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286964.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4IXW7, X2JAR2
    Conserved Domains (6) summary
    cd00096
    Location:630 → 699
    Ig; Immunoglobulin domain
    smart00408
    Location:533 → 597
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:432 → 517
    IG_like; Immunoglobulin like
    cd00063
    Location:906 → 1001
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:521 → 610
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:725 → 802
    Ig; Immunoglobulin domain

  3. NM_001300036.1 → NP_001286965.1  down syndrome cell adhesion molecule 2, isoform R [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286965.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4IXW9, X2JGC8
    Conserved Domains (6) summary
    cd00096
    Location:822 → 893
    Ig; Immunoglobulin domain
    smart00408
    Location:533 → 597
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:432 → 517
    IG_like; Immunoglobulin like
    cd00063
    Location:905 → 1000
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:521 → 610
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:724 → 801
    Ig; Immunoglobulin domain

  4. NM_168194.4 → NP_729223.2  down syndrome cell adhesion molecule 2, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729223.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VS29
    Conserved Domains (6) summary
    cd00096
    Location:822 → 893
    Ig; Immunoglobulin domain
    smart00408
    Location:533 → 597
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:432 → 517
    IG_like; Immunoglobulin like
    cd00063
    Location:905 → 1000
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:521 → 610
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:724 → 801
    Ig; Immunoglobulin domain

  5. NM_001274570.2 → NP_001261499.1  down syndrome cell adhesion molecule 2, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261499.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEU0
    Conserved Domains (6) summary
    cd00096
    Location:822 → 893
    Ig; Immunoglobulin domain
    smart00408
    Location:533 → 597
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:432 → 517
    IG_like; Immunoglobulin like
    cd00063
    Location:905 → 1005
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:521 → 610
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:724 → 801
    Ig; Immunoglobulin domain

  6. NM_001274569.2 → NP_001261498.1  down syndrome cell adhesion molecule 2, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261498.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PED2
    Conserved Domains (6) summary
    cd00096
    Location:630 → 699
    Ig; Immunoglobulin domain
    smart00408
    Location:533 → 597
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:432 → 517
    IG_like; Immunoglobulin like
    cd00063
    Location:906 → 1006
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:521 → 610
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:725 → 802
    Ig; Immunoglobulin domain

  7. NM_001274571.2 → NP_001261500.1  down syndrome cell adhesion molecule 2, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261500.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEK5
    Conserved Domains (6) summary
    cd00096
    Location:630 → 699
    Ig; Immunoglobulin domain
    smart00408
    Location:533 → 597
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:432 → 517
    IG_like; Immunoglobulin like
    cd00063
    Location:906 → 1006
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:521 → 610
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:725 → 802
    Ig; Immunoglobulin domain

  8. NM_001316478.1 → NP_001303407.1  down syndrome cell adhesion molecule 2, isoform S [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0S0WFE8
    Conserved Domains (6) summary
    cd00096
    Location:630 → 699
    Ig; Immunoglobulin domain
    smart00408
    Location:533 → 597
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:432 → 517
    IG_like; Immunoglobulin like
    cd00063
    Location:906 → 1006
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:521 → 610
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:725 → 802
    Ig; Immunoglobulin domain

  9. NM_001169896.3 → NP_001163367.1  down syndrome cell adhesion molecule 2, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163367.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4IXW7, E1JI62
    Conserved Domains (6) summary
    cd00096
    Location:630 → 699
    Ig; Immunoglobulin domain
    smart00408
    Location:533 → 597
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:432 → 517
    IG_like; Immunoglobulin like
    cd00063
    Location:906 → 1006
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:521 → 610
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:725 → 802
    Ig; Immunoglobulin domain

  10. NM_001043123.3 → NP_001036588.2  down syndrome cell adhesion molecule 2, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036588.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4IXW7
    Conserved Domains (6) summary
    cd00096
    Location:630 → 699
    Ig; Immunoglobulin domain
    smart00408
    Location:533 → 597
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:432 → 517
    IG_like; Immunoglobulin like
    cd00063
    Location:906 → 1001
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:521 → 610
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:725 → 802
    Ig; Immunoglobulin domain

  11. NM_001144424.2 → NP_001137896.1  down syndrome cell adhesion molecule 2, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137896.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4IXW9
    Conserved Domains (6) summary
    cd00096
    Location:822 → 893
    Ig; Immunoglobulin domain
    smart00408
    Location:533 → 597
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:432 → 517
    IG_like; Immunoglobulin like
    cd00063
    Location:905 → 1000
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:521 → 610
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:724 → 801
    Ig; Immunoglobulin domain

  12. NM_168195.3 → NP_729224.2  down syndrome cell adhesion molecule 2, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729224.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4IXW9
    Conserved Domains (6) summary
    cd00096
    Location:822 → 893
    Ig; Immunoglobulin domain
    smart00408
    Location:533 → 597
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:432 → 517
    IG_like; Immunoglobulin like
    cd00063
    Location:905 → 1000
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:521 → 610
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:724 → 801
    Ig; Immunoglobulin domain

  13. NM_001169897.2 → NP_001163368.1  down syndrome cell adhesion molecule 2, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163368.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4IXW9, E1JI61
    Conserved Domains (6) summary
    cd00096
    Location:822 → 893
    Ig; Immunoglobulin domain
    smart00408
    Location:533 → 597
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:432 → 517
    IG_like; Immunoglobulin like
    cd00063
    Location:905 → 1005
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:521 → 610
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:724 → 801
    Ig; Immunoglobulin domain

  14. NM_001144426.2 → NP_001137898.1  down syndrome cell adhesion molecule 2, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137898.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4IJ57
    Conserved Domains (5) summary
    cd00096
    Location:632 → 699
    Ig; Immunoglobulin domain
    smart00408
    Location:533 → 597
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:432 → 517
    IG_like; Immunoglobulin like
    pfam07679
    Location:521 → 610
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:247 → 327
    Ig; Immunoglobulin domain

  15. NM_001144425.2 → NP_001137897.1  down syndrome cell adhesion molecule 2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137897.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H5V8G2
    Conserved Domains (4) summary
    smart00408
    Location:436 → 507
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:432 → 517
    IG_like; Immunoglobulin like
    pfam07679
    Location:238 → 327
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:247 → 327
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0S0WFE8 A0A0S0WFE8
E1JI61 E1JI61
E1JI62 E1JI62
M9PED2 M9PED2
M9PEK5 M9PEK5
M9PEU0 M9PEU0
Q9VS29.3 Q9VS29
X2JAR2 X2JAR2
X2JGC8 X2JGC8

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