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RhoGEF4 - Rho guanine nucleotide exchange factor 4

Enables guanyl-nucleotide exchange factor activity. Involved in cleavage furrow ingression; positive regulation of Rho protein signal transduction; and positive regulation of stress fiber assembly. Located in midbody; mitotic actomyosin contractile ring; and nucleus. Is expressed in several structures, including CNS glial cell; antennal anlage; antennal primordium; ganglia; and head epidermis primordium. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4H. Orthologous to human FGD4 (FYVE, RhoGEF and PH domain containing 4) and ARHGEF39 (Rho guanine nucleotide exchange factor 39). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa