Rint1 RAD50 interactor 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rint1provided by FlyBase
Official Full Name: RAD50 interactor 1provided by FlyBase
Primary source: FLYBASE:FBgn0035762
Locus tag: Dmel_CG8605
See related: AllianceGenome:FB:FBgn0035762
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8605; Dmel\CG8605; Rint-1; rint1; Tip20
Summary: Involved in Golgi organization; cleavage furrow ingression; and male meiosis cytokinesis. Predicted to be located in endoplasmic reticulum. Predicted to be part of Dsl1/NZR complex. Is expressed in several structures, including adult head; embryonic/larval salivary gland; gut section; hindgut proper primordium; and posterior midgut primordium. Human ortholog(s) of this gene implicated in infantile liver failure syndrome. Orthologous to human RINT1 (RAD50 interactor 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (7323619..7326255)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (7316719..7319355)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Golgi vesicle transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cleavage furrow ingression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in male meiosis cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ER to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Dsl1/NZR complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Dsl1/NZR complex	IEA Inferred from Electronic Annotation more info
part_of Dsl1/NZR complex	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info

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The following sections contain reference sequences that belong to a specific genome build. Explain