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qm quemao [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38816, updated on 9-Dec-2024

Summary

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Official Symbol
qmprovided by FlyBase
Official Full Name
quemaoprovided by FlyBase
Primary source
FLYBASE:FBgn0019662
Locus tag
Dmel_CG8593
See related
AllianceGenome:FB:FBgn0019662
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
bro2; CG8593; Dmel\CG8593; GGPPS; GGPPS/qm; Qm
Summary
Predicted to enable farnesyltranstransferase activity. Involved in embryonic heart tube development; germ cell migration; and oogenesis. Is expressed in several structures, including adult head; indirect flight muscle cell; larval visceral muscle cell; and visceral muscle primordium. Orthologous to human GGPS1 (geranylgeranyl diphosphate synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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Location:
65F5-65F6; 3-20 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7348313..7353622)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7341413..7346722)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Signal recognition particle 19 Neighboring gene long non-coding RNA:CR45833 Neighboring gene CTCF Neighboring gene antisense RNA:CR45822 Neighboring gene pastrel

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A homologue of the 19 kDa signal recognition particle protein locus in Drosophila melanogaster. Lai C, et al. Gene, 1997 Dec 5. PMID 9426007
  2. quemao, a Drosophila bristle locus, encodes geranylgeranyl pyrophosphate synthase. Lai C, et al. Genetics, 1998 Jun. PMID 9611212, Free PMC Article
  3. The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. Yi P, et al. Science, 2006 Sep 1. PMID 16857902
  4. Coordinated control of dCTCF and gypsy chromatin insulators in Drosophila. Gerasimova TI, et al. Mol Cell, 2007 Dec 14. PMID 18082602, Free PMC Article
  5. Ggamma1, a downstream target for the hmgcr-isoprenoid biosynthetic pathway, is required for releasing the Hedgehog ligand and directing germ cell migration. Deshpande G, et al. PLoS Genet, 2009 Jan. PMID 19132091, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables farnesyltranstransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables farnesyltranstransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables prenyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in embryonic heart tube development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in isoprenoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
quemao
Names
CG8593-PA
CG8593-PB
CG8593-PC
geranylgeranyl pyrophosphate synthase
qm-PA
qm-PB
qm-PC
que mao
NP_001163370.1
NP_001261510.1
NP_523958.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    7348313..7353622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169899.2 → NP_001163370.1  quemao, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163370.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61539, Q9VS54
    Conserved Domains (1) summary
    pfam00348
    Location:30 → 267
    polyprenyl_synt; Polyprenyl synthetase

  2. NM_079234.4 → NP_523958.2  quemao, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523958.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61539, Q9VS54
    Related
    FBpp0076557
    Conserved Domains (1) summary
    pfam00348
    Location:30 → 267
    polyprenyl_synt; Polyprenyl synthetase

  3. NM_001274581.1 → NP_001261510.1  quemao, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261510.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEL3, O61539
    Conserved Domains (1) summary
    pfam00348
    Location:30 → 255
    polyprenyl_synt; Polyprenyl synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PEL3 M9PEL3
O61538 O61538
O61539 O61539
Q5G1W2 Q5G1W2
Q9VS54 Q9VS54

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