akirin akirin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: akirinprovided by FlyBase
Official Full Name: akirinprovided by FlyBase
Primary source: FLYBASE:FBgn0082598
Locus tag: Dmel_CG8580
See related: AllianceGenome:FB:FBgn0082598
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Akirin; anon-WO0118547.397; bhr; CG8580; DmAkirin; Dmel\CG8580; EP(3)0906
Summary: Enables transcription coregulator activity. Involved in several processes, including defense response to Gram-negative bacterium; larval somatic muscle development; and positive regulation of peptidoglycan recognition protein signaling pathway. Located in euchromatin; nucleus; and polytene chromosome. Is expressed in organism. Used to study opportunistic bacterial infectious disease. Orthologous to human AKIRIN1 (akirin 1) and AKIRIN2 (akirin 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (7369843..7373711)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (7362943..7366811)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables transcription coregulator activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed

Names: CG8580-PA; CG8580-PB; CG8580-PC; CG8580-PD; CG8580-PE; CG8580-PF; akirin-PA; akirin-PB; akirin-PC; akirin-PD; akirin-PE; akirin-PF; bhringi