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SBK1 SH3 domain binding kinase 1 [ Homo sapiens (human) ]

Gene ID: 388228, updated on 27-Nov-2024

Summary

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Official Symbol
SBK1provided by HGNC
Official Full Name
SH3 domain binding kinase 1provided by HGNC
Primary source
HGNC:HGNC:17699
See related
Ensembl:ENSG00000188322 MIM:620212; AllianceGenome:HGNC:17699
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SBK
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in chromatin remodeling and protein phosphorylation. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in brain (RPKM 3.9), prostate (RPKM 1.1) and 16 other tissues See more
Orthologs
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Genomic context

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See SBK1 in Genome Data Viewer
Location:
16p12.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (28258681..28323849)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (28539191..28604353)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28303846..28335170)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene exportin 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7305 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:28203444-28203616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10639 Neighboring gene RNY1 pseudogene 10 Neighboring gene Sharpr-MPRA regulatory region 6679 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:28222406-28223404 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:28230517-28231018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28234253-28235103 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 35 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28271835-28272335 Neighboring gene Sharpr-MPRA regulatory region 11993 Neighboring gene uncharacterized LOC124903670 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:28303338-28303509 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7307 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28341775-28342274 Neighboring gene MPRA-validated peak2550 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28347523-28348022 Neighboring gene nuclear pore complex interacting protein family member B6 Neighboring gene microRNA 6862-1 Neighboring gene eukaryotic translation initiation factor 3 subunit C like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SH3 domain-binding kinase 1 promotes proliferation and inhibits apoptosis of cervical cancer via activating the Wnt/β-catenin and Raf/ERK1/2 signaling pathways. Chen X, et al. Mol Carcinog, 2023 Aug. PMID 37132991
  2. Human SBK1 is dysregulated in multiple cancers and promotes survival of ovary cancer SK-OV-3 cells. Wang P, et al. Mol Biol Rep, 2011 Jun. PMID 21104019
  3. Cloning and characterization of a novel serine/threonine protein kinase gene expressed predominantly in developing brain. Nara K, et al. Eur J Biochem, 2001 May. PMID 11322885
  4. Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes. Linkermann A, et al. Biochim Biophys Acta, 2009 Feb. PMID 19041431
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Trynka G, et al. Gut, 2009 Aug. PMID 19240061

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SH3 domain-binding kinase 1 promotes proliferation and inhibits apoptosis of cervical cancer via activating the Wnt/beta-catenin and Raf/ERK1/2 signaling pathways.
    Title: SH3 domain-binding kinase 1 promotes proliferation and inhibits apoptosis of cervical cancer via activating the Wnt/β-catenin and Raf/ERK1/2 signaling pathways.
  2. Results suggest that the wide-spread expression pattern of human SBK1 may predict a broad cellular function, and its dysregulation in certain cancers suggests an involvement of the protein in the pathogenesis of human cancers.
    Title: Human SBK1 is dysregulated in multiple cancers and promotes survival of ovary cancer SK-OV-3 cells.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase SBK1
Names
SH3-binding domain kinase 1
NP_001019572.1
XP_005255372.1
XP_054236286.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024401.3 → NP_001019572.1  serine/threonine-protein kinase SBK1

    See identical proteins and their annotated locations for NP_001019572.1

    Status: VALIDATED

    Source sequence(s)
    AY874862
    Consensus CDS
    CCDS32416.1
    UniProtKB/Swiss-Prot
    Q52WX2
    UniProtKB/TrEMBL
    A0A590UK17
    Related
    ENSP00000343248.4, ENST00000341901.5
    Conserved Domains (2) summary
    smart00220
    Location:53 → 316
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13987
    Location:59 → 317
    STKc_SBK1; Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    28258681..28323849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255315.5 → XP_005255372.1  serine/threonine-protein kinase SBK1 isoform X1

    UniProtKB/TrEMBL
    A0A590UK17
    Related
    ENSP00000499661.3, ENST00000671413.3
    Conserved Domains (2) summary
    smart00220
    Location:87 → 350
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13987
    Location:93 → 351
    STKc_SBK1; Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    28539191..28604353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380311.1 → XP_054236286.1  serine/threonine-protein kinase SBK1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q52WX2.1 GenPept UniProtKB/Swiss-Prot:Q52WX2

Gene LinkOut

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