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CG8560 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38830, updated on 9-Dec-2024

Summary

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Official Symbol
CG8560provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0035781
Locus tag
Dmel_CG8560
See related
AllianceGenome:FB:FBgn0035781
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CT14378; Dmel\CG8560
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in adult head; dorsal sensory complex proper primordium; embryonic proventriculus; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in familial febrile seizures 11 and familial temporal lobe epilepsy 5. Orthologous to human CPA6 (carboxypeptidase A6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG8560 in Genome Data Viewer
Location:
65F11-65F11; 3-20 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7402332..7404181, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7395432..7397281, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR33948 Neighboring gene long non-coding RNA:CR44525

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Buffering and proteolysis are induced by segmental monosomy in Drosophila melanogaster. Lundberg LE, et al. Nucleic Acids Res, 2012 Jul. PMID 22434883, Free PMC Article
  2. Introgression in the Drosophila subobscura--D. Madeirensis sister species: evidence of gene flow in nuclear genes despite mitochondrial differentiation. Herrig DK, et al. Evolution, 2014 Mar. PMID 24152112, Free PMC Article
  3. Genomic response to selection for postponed senescence in Drosophila. Wilson RH, et al. Mech Ageing Dev, 2013 Mar. PMID 23262286, Free PMC Article
  4. New comparative genomics approach reveals a conserved health span signature across species. Antosh M, et al. Aging (Albany NY), 2011 Jun. PMID 21775776, Free PMC Article
  5. Single-cell transcriptome characteristics of testicular terminal epithelium lineages during aging in the Drosophila. Chen X, et al. Aging Cell, 2024 Mar. PMID 38044573, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG8560-PA
CG8560-PB
NP_001261516.1
NP_648120.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    7402332..7404181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139863.4 → NP_648120.3  uncharacterized protein Dmel_CG8560, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648120.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961J8, Q9VS68
    Related
    FBpp0076578
    Conserved Domains (2) summary
    cd03860
    Location:123 → 414
    M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
    pfam02244
    Location:29 → 98
    Propep_M14; Carboxypeptidase activation peptide

  2. NM_001274587.1 → NP_001261516.1  uncharacterized protein Dmel_CG8560, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261516.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961J8, Q9VS68
    Conserved Domains (2) summary
    cd03860
    Location:123 → 414
    M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
    pfam02244
    Location:29 → 98
    Propep_M14; Carboxypeptidase activation peptide
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q961J8 Q961J8

Gene LinkOut

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