U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tsp66A Tetraspanin 66A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38836, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Tsp66Aprovided by FlyBase
Official Full Name
Tetraspanin 66Aprovided by FlyBase
Primary source
FLYBASE:FBgn0035786
Locus tag
Dmel_CG16991
See related
AllianceGenome:FB:FBgn0035786
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG16991; Dm.Tsp66A; Dmel\CG16991
Summary
Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tsp66A in Genome Data Viewer
Location:
66A2-66A2; 3-21 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7465509..7468808)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7458609..7461908)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pickpocket 26 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. Fradkin LG, et al. Proc Natl Acad Sci U S A, 2002 Oct 15. PMID 12370414, Free PMC Article
  2. The tetraspanin superfamily in insects. Todres E, et al. Insect Mol Biol, 2000 Dec. PMID 11122467
  3. Changes in organelle position and epithelial architecture associated with loss of CrebA. Fox RM, et al. Biol Open, 2015 Feb 13. PMID 25681391, Free PMC Article
  4. Minos as a genetic and genomic tool in Drosophila melanogaster. Metaxakis A, et al. Genetics, 2005 Oct. PMID 15972463, Free PMC Article
  5. The Septate Junction Protein Tsp2A Restricts Intestinal Stem Cell Activity via Endocytic Regulation of aPKC and Hippo Signaling. Xu C, et al. Cell Rep, 2019 Jan 15. PMID 30650359, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tetraspanin 66A
Names
CG16991-PC
CG16991-PD
CG16991-PE
CG16991-PF
Tsp66A-PC
Tsp66A-PD
Tsp66A-PE
Tsp66A-PF

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    7465509..7468808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202134.1 → NP_001189063.1  tetraspanin 66A, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189063.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQ78
    Conserved Domains (2) summary
    cd03127
    Location:95 → 181
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:25 → 212
    Tetraspannin; Tetraspanin family

  2. NM_001274589.2 → NP_001261518.1  tetraspanin 66A, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261518.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEE6
    Conserved Domains (2) summary
    cd03127
    Location:97 → 183
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:25 → 214
    Tetraspannin; Tetraspanin family

  3. NM_168216.4 → NP_729259.2  tetraspanin 66A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729259.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IQ78
    Conserved Domains (2) summary
    cd03127
    Location:95 → 181
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:25 → 212
    Tetraspannin; Tetraspanin family

  4. NM_001274590.2 → NP_001261519.1  tetraspanin 66A, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261519.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PEV5
    Conserved Domains (2) summary
    cd03127
    Location:95 → 179
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:25 → 210
    Tetraspannin; Tetraspanin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PEE6 M9PEE6
M9PEV5 M9PEV5
Q8IQ78 Q8IQ78
Q8MZG8 Q8MZG8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools