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Cyp4d8 Cytochrome P450 4d8 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38841, updated on 9-Dec-2024

Summary

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Official Symbol
Cyp4d8provided by FlyBase
Official Full Name
Cytochrome P450 4d8provided by FlyBase
Primary source
FLYBASE:FBgn0015033
Locus tag
Dmel_CG4321
See related
AllianceGenome:FB:FBgn0015033
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
4d8; CG4321; Cyp4D8; CYP4d8; CYP4D8; Dmel\CG4321; P-450; P450
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head and embryonic/larval midgut. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Cyp4d8 in Genome Data Viewer
Location:
66A2-66A2; 3-21 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7493557..7496197, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7486657..7489279, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene methuselah-like 6 Neighboring gene Cytochrome P450 316a1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cytochrome P450 gene clusters in Drosophila melanogaster. Dunkov BC, et al. Mol Gen Genet, 1996 Jun 12. PMID 8676871
  2. Effects of the adenylate cyclase activator forskolin and its inactive derivative 1,9-dideoxyforskolin on insect cytochrome P-450 dependent steroid hydroxylase activity. Keogh DP, et al. Experientia, 1992 Jan 15. PMID 1737575
  3. Alkaloid metabolism by cytochrome P-450 enzymes in Drosophila melanogaster. Danielson PB, et al. Comp Biochem Physiol B Biochem Mol Biol, 1995 Apr. PMID 7749620
  4. [Ethanol inhibits recombination in somatic cells of gamma-irradiated larvae of Drosophila melanogaster]. Zakharenko LP, et al. Genetika, 1998 Mar. PMID 9589864
  5. Transcriptome analysis of Drosophila suzukii reveals molecular mechanisms conferring pyrethroid and spinosad resistance. Tabuloc CA, et al. Sci Rep, 2024 Aug 27. PMID 39191909, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 4d8
Names
CG4321-PB
Cyp4d8-PB
cytochrome P450
cytochrome P450-4d8
NP_523961.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    7493557..7496197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079237.3 → NP_523961.2  cytochrome P450 4d8 [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24127, Q95TY3, Q9VS79
    Conserved Domains (1) summary
    cd20628
    Location:66 → 497
    CYP4; cytochrome P450 family 4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VS79.2 Q9VS79

Gene LinkOut

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