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mmm missing minor mitochondria [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38851, updated on 9-Dec-2024

Summary

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Official Symbol
mmmprovided by FlyBase
Official Full Name
missing minor mitochondriaprovided by FlyBase
Primary source
FLYBASE:FBgn0035799
Locus tag
Dmel_CG14838
See related
AllianceGenome:FB:FBgn0035799
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14838; Dmel\CG14838
Summary
Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Involved in flagellated sperm motility. Located in sperm flagellum. Is expressed in gonad; spermatogonium; and spermatozoon. Orthologous to human DNAI3 (dynein axonemal intermediate chain 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See mmm in Genome Data Viewer
Location:
66A6-66A6; 3-21 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7583454..7587248)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7576554..7580348)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene faulty attraction Neighboring gene testis-specific gamma-tubulin ring protein 84 Neighboring gene Puratrophin-1-like Neighboring gene long non-coding RNA:CR45866

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Impact of cilia-related genes on mitochondrial dynamics during Drosophila spermatogenesis. Bauerly E, et al. Dev Biol, 2022 Feb. PMID 34822845
  2. Environmental chemical mediated male reproductive toxicity: Drosophila melanogaster as an alternate animal model. Tiwari AK, et al. Theriogenology, 2011 Jul 15. PMID 21356551
  3. Diverse Roles of Axonemal Dyneins in Drosophila Auditory Neuron Function and Mechanical Amplification in Hearing. Karak S, et al. Sci Rep, 2015 Nov 26. PMID 26608786, Free PMC Article
  4. Functional analysis of the Drosophila embryonic germ cell transcriptome by RNA interference. Jankovics F, et al. PLoS One, 2014. PMID 24896584, Free PMC Article
  5. Structure and molecular basis of spermatid elongation in the Drosophila testis. Huang Q, et al. Open Biol, 2023 Nov. PMID 37935354, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inner dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of inner dynein arm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
missing minor mitochondria
Names
CG14838-PA
mmm-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    7583454..7587248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139881.2 → NP_648138.1  missing minor mitochondria [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648138.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8WHE4, Q9VS90
    Related
    FBpp0076513
    Conserved Domains (3) summary
    COG2319
    Location:328 → 599
    WD40; WD40 repeat [General function prediction only]
    pfam09522
    Location:807 → 863
    RE_R_Pab1; R.Pab1 restriction endonuclease
    sd00039
    Location:462 → 505
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VS90 Q9VS90

Gene LinkOut

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